Wound-healing activity of Hydroxytriazenes–A new cl ass of Bioactive compounds


Abstract 

In the present study, the wound-healing activity of some substituted hydroxytriazenes was investigated. Excision, resutured incision and deadspace wound models were used to evaluate the wound-healing activity of substituted hydroxytriazenes. In excision wound model, treatment was continued till the complete healing of the wound, in incision and dead space wound models the treatment was continued for 10 days. For topical application, 5% w/w ointment of hydroxytriazenes was prepared in 2% sodium alginate and for oral administration hydroxytriazenes dissolved in DMSO, at dose 5 mg/kgwere used. In excision and incision wound models, the control group of animals was leftuntreated and in dead space wound models the animals were treated with DMSO (1ml/kg). The healing of the wound was assessed by the rate of wound contraction, period of epithelialisation, skin breaking strength, granulation strength, dry granulation tissue weight and hydroxyproline estimation. Except the parent compound (HD-1), rest of the hydroxytriazenes (HD-2and HD-3) significantly promoted the wound-healing activity in all the three wound models.

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