Design development and evaluation of extended relea se tablets of Alfuzosin hydrochloride


Abstract 

Alfuzosin hydrochloride(HCl) was formulated as oral extended release matrix tablets using polymers like sodium alginate, ethyl cellulose( EC), hydroxyl propyl methyl cellulose (HPMC K100) and hydrogenated castor oil (HCO).Matrix tablets were prepared by wet granulation method. Tablets were prepared with drug to polymer ratios 1:5, 1:10, 1:15 and 1:20.The formulated tablets were evaluated for various physicochemical parameters by official procedures. The invitro release study of the matrix tablets were carried out in 0.1N HCl for 2hrs at pH 1.2 and pH 6.8 buffer for the next 22 hours. Based on drug release rate, polymers can be arranged as sodium alginate > EC >HPMC >HC

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