Simultaneous estimation and validation of Rabeprazo le Sodium and Diclofenac Sodium in capsule dosage form


Abstract

Six simple, rapid, accurate, precise and cost-effective methods, I; formation and solving of simultaneous equation method, II; absorbance ratio method, III; dual wave length method, IV; area under curve method, V; first order derivative spectrophotometry method and VI; multi-component method have been developed for simultaneous estimation of rabeprazole sodium and diclofenac sodium in capsule dosage form. Rabeprazole sodium showed absorbance maxima at 292 nm and diclofenac sodium showed at 276 nm in 0.01N NaOH solution. Beer’s law was obeyed in concentration range 5-30 μg/mlfor rabeprazole sodium and 5-35 μg/ml for diclofenac sodium respectively for all proposed six methods. The sampling wavelengths for method VI, selected for both the drugs were 260nm, 276nm, 286nm, 292nm and 295 nm on trial and error basis using 0.01 N NaOH solutions as solvent.

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