Synthesis and pharmacological evaluation of some substituted imidazoles

Introduction

Epilepsy is a group of disorders of the CNS characterized by paroxysmal cerebral dysthymia, manifesting as brief episodes (seizures) of loss or disturbance of consciousness, with or without characteristic body movements (convulsions), sensory or psychiatric phenomena. Epilepsy is a common chronic neurological disorder characterized by recurrent unprovoked seizures. These seizures are transient sign and /or symptoms of abnormal, excessive or synchronous neuronal activity in the brain. Epilepsy has a focal origin in the, manifestations depends on the site of the focus, regions into which the discharges spread anpostical depression of these regions. About 50 million people worldwide have epilepsy, with almost 90% of these people being in developing countries. Epilepsy is more likely to occur in young children or people over the age of 65 years; however it can occur at any time.