Journal of Chemical and Pharmaceutical Research

ABSTRACT Earthworm plays a major role in the proper functioning of the soil ecosystem. It acts as scavenger and helps in recycling of dead and decayed plant material by feeding on them. Earthworm increases the soil fertility and is often referred to as a farmer’s friend. Earthworms have been used in medicine for various remedies. In the present investigation, various solvent extracts of an earthworm, Eudrilus eugeniae were prepared and antimicrobial activity of these extracts were determined by well diffusion method.

ABSTRACT Poloxamer 407 is used primarily as a thickening agent and gel former, but also as a co-emulsifier and consistency enhancer in creams and liquid emulsions. It is also used as a solubilizer for certain active substances Moreover, Poloxamer 407 is suitable for the formulation of active substances that show reduced solubility as a result of neutralization. Poloxamer 407 is reported to possess transparency, film forming properties and useful in formation of gel. The aceclofenac gels were prepared by using different concentration of Poloxamer 407 for topical drug delivery with an objective to increase transparency and spreadability.

ABSTRACT Comparison of seismic velocities in mantle metals under mantle conditions with seismic data is the first step towards constraining mantle chemistry. The calculation, however, is uncertain due to lack of data on certain physical properties. The Grüneisen parameter ( γ ) is of much importance regarding to the physical properties of mantle metals, because it sets limitations on the thermo elastic properties of the lower mantle and core at different compression ratio.

ABSTRACT Various Chromene -2- one derivatives (1a-1f) were synthesized and evaluated for antipsychotic activity. All the synthesized compounds showed antipsychotic activity with muscle relaxant property. The compound 1d, N-(Fluoro benzothiazol-2-yl)-(4-Methyl-2-oxo-chromene-7-yloxy) acetamide has been found to have significant atypical behaviour.

ABSTRACT Benzoxazine and its derivatives are used in organic synthesis for building natural and designed synthetic compounds and they have been frequently utilized as suitable skeletons for the design of biologically active compound. This review coversupdated information on the most active benzoxazine derivatives that have been reported to show considerable pharmacological actions such as antimicrobial, antimycobacterial, anti-diabetic, antihypolipidaemic, and antidepressant. It can act as an important tool for chemists to develop newer benzoxazine derivatives that may prove to be better agents in terms of efficacy and safety.