Formulation Design of Fast Dissolving Tablets of Granisetron Using Effervescent Blend with Improved Efficacy


ABSTRACT
In the present work, fast dissolving tablets of granisetron HCl were prepared by effervescent method with a view to enhance patient compliance .Croscarmellose sodium is used as a superdisintigrant along with blend of sodium bicarbonate, anhydrous citric acid and tartaric acid in different ratios (as effervescent material)were used and directly compressible mannitol (Pearlitol SD 200) to enhance mouth feel. The prepared batches of tablets were evaluated for hardnss.

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