Formulation Development and evaluation of Fast Dissolving Tablets of Carvedilol


ABSTRACT:

Carvedilol is a poorly water soluble oral antihypertensive agent, with problems of variable bioavailability and bioequivalence related to its poor water solubility. Carvedilol is a nonselective beta adrenergic blocking agent with alpha-1 blocking activity and is indicated for the treatment of hypertension and mild to moderate heart failure of ischematic or cardiomyopathic origin In the present work solubility was enhanced by using β- cyclodextrin as a complexing agent. Sweeteners and flavors were used to enhance the organoleptic properties of tablet. Solubility studies were performed to investigate the drug carrier interaction. I.R. and D.S.C studies carried out to investigate any interaction and stability of formulation. Tablets were prepared by direct compression technique. Prepared tablets were evaluated for thickness, uniformity of weight, hardness, friability, wetting time, in-vitro disintegration time, drug content and in vitro drug release. All the formulations were evaluated for the influence of disintegrates and their concentrations on the characteristics of fast dissolving tablets mainly in terms of disintegration time and dissolution studies. Optimized formulation of Ac-Di-Sol Superdisintegrant in the concentration of (6mg) i.e. F3 batch gives best results than all the formulation. Formulation F3 of Ac-Di-sol superdisintegrant required minimum disintegration time, wetting time Compared to Formulations of Crosspovidone, or Sodium-starch glycoate with same concentration. From this study it can be concluded that Carvedilol can be successfully complexed with Beta-cyclodextrin to prepare fast dissolving tablets in the ratio of 1: 4.

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