Synthesis and antimicrobial activity of some new chalcones and flavones containing substituted naphthalene moiety


ABSTRACT:

Seven new chalcones and flavones containing substitued naphthalene nucleus in their structure were synthesized and the structures of these compounds were confirmed by spectral data. The newly synthesized compounds were screened for antibacterial activity against Escherichia coli and Stahylococcus aureus.

Introduction:

 The flavoniods have been reported to possess a wide range of biological activites such as antimicrobial, anticancer, antioxidant, antinocicepative, anti-inflammatory, antihypertensive and antifeedant. In view of these observations and in continuation of our work on biologically active chalcones and their heterocycles, we have been planned to synthesize the some new flavones (IIa-h) from chalcones (Ia-h) and also studied their antibacterial activity against Escherichia coli (E. coli) and Stahylococcus aureus (S. aureus) using Tetracycline as a standard drug.

Further details @ http://www.jocpr.com/

For more details @ http://www.jocpr.com/articles/synthesis-and-antimicrobial-activity-of-some-new-chalcones-and-flavones-containing-substituted-naphthalene-moiety.pdf

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