Synthesis, characterization and antimicrobial studies on Cobalt (II), Nickel (II), Copper (II) and Zinc (II) complexes of N, O, S donor Schiff bases


ABSTRACT:

Biologically important Schiff bases L1 8-nitro-2-{[(5'-methyl-3'-isoxazolyl) imino] methyl} naphtha [NMIIMN], L2 N-[5'-methyl-3'-isoxazolyl]-N-[(E)-1-(-2 Thiophene)] methylidine] amine [MITMA] have been synthesized. Metal Chelates of NMIIMN and MITMA with Co (II), Ni (II), Cu (II) and Zn (II) metals have been synthesized and the structures of these chelates have been elucidated by elemental analysis, 1H _NMR, Mass, IR electronic spectral data and magnetic moments. From these studies it is found that the ligands NMIIMN and MITMA act as bidentate ligands coordinating through oxygen and nitrogen donor atoms in the case of NMIIMN, sulpher and nitrogen atoms in the case of MITMA. The chelates of Co (II), Ni (II) and Zn (II) appear to be octahedral and Cu (II) appears to be tetragonal geometry. Antimicrobial activity of the ligands and their metal complexes against bacteria (Bacillus, Pseudomonas) and fungus (R. Solani, A. Niger) has been carried out. It is found that the metal complexes have higher activities than those of free ligands.

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