Synthesis of some new 2-amino-3-cyano-4-aryl-6-(1-napthyl amino)- pyridines as antibacterial agents

ABSTRACT:

Variety of 2-amino-3-cyano-4-aryl-6-(1-napthyl amino)-pyridines 3(a-h) have been synthesized by reacting 1-(1-napthyl amino)-3-aryl-2-propen-1-ones 2(a-h) with malononitrile and ammonium acetate in methanol under reflux condition. Structures of the synthesized compounds were confirmed by the spectral analysis. Furthermore, all the synthesized products were screened for their antibacterial activity.

Introduction:

Among the wide variety of heterocycles that have been explored developing pharmaceutically important molecules like pyridines, cyano-pyridines have played an important role in the heterocyclic chemistry. Pyridine derivatives have occupied a unique position in medicinal chemistry. The naturally occurring B6-vitamins pyridoxine, pyrodoxal, pyridoxamine, and codecarbaxylase contain a pyridine nucleus. In addition to this, many naturallly occurring and synthetic compounds containing the pyridine scaffold possess interesting pharmacological properties. Among them, 2-amino-3-cyanopyridines have been identified as IKK-β inhibitors. Besides, they are important and useful intermediates in preparing variety of heterocyclic compounds. Therefore, the synthesis of 2-amino-3-cyanopyridine derivatives continues to attract much interest in organic chemistry. In this respect, and also in continuation of our earlier work on synthesis of different heterocyclic system that containing highly biological activity, these assets prompted us to prepare some new cyano-pyridines with potential biological activity.

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