Journal of Chemical and Pharmaceutical Research

Simple, sensitive and precise spectrophotometric methods have been developed for the estimation of valacyclovir, aceclofenac, racecadotril, valdecoxib, nebivolol and reboxetine in bulk and pharmaceutical dosage forms. Methanol and triple distilled water were used as solvents for the estimation of all these drugs. Absorption maxima of all the above drugs were determined and the estimations were carried out in tablet dosage forms. Results of the analysis were validated statistically and by recovery studies. PDF

Asthma affects 7% population of the United States, 6.5% of British population and a total of 300 million people worldwide. It affects over 5-10% of the population in industrialized countries. Asthma is characterized by a predisposition to chronic inflammation of the lungs in which the airways (bronchi) are reversibly narrowed resulting in difficulty in breathing. The agents responsible for the early reaction (immediate bronchoconstriction) include- histamine, tryptase, and other neutral proteases, leukotrienes C4 & D4 and prostaglandins. Synthetic drugs may give instant relief from symptoms of asthma, but have lot of undesirable effects (like those of steroids). Herbal drugs (Tylophora, Coleus, Ephedra, Boswelia and Ginkgo etc.) as reported in ancient literature and screened for pharmacological activity are an excellent option for the treatment of various ailments including asthma. PDF

Chirayata is an excellent remedy for strengthening the stomach and promoting its action. It is used in the treatment of dyspepsia and diarrhea. Chiretta stimulates the digestion and helps to normalize blood sugar, which makes it useful for diabetics. Studies with animals suggest that this herb reduces the sugar levels only when they are high, which lowers the risk of hypoglycemia. The bitterness of the herb stimulates saliva and gastric juices, which help stop nausea, bloating, indigestion and hiccups. It is also used for fever and to rid the body of parasites. It is a tonic for the heart, liver and eyes, and can be useful to relieve sciatica, cough, scanty urine and melancholia.Chiretta is used as a preventative measure for malaria during epidemics. It is given as a tonic to people convalescing from a long illness. This herb is antimicrobial. Studies are underway to see if this herb continues to offer a reduction in cancer cells when taken to fight cancer Its medicinal uses are Bitt...

Antioxidants are an inhibitor of the process of oxidation, even at relatively small concentration and thus have diverse physiological role in the body. Antioxidant constituents of the plant material act as radical scavengers, and helps in converting the radicals to less reactive species. A variety of free radical scavenging antioxidants is found in dietary sources like fruits, vegetables and tea, etc. This review presents some information about the antioxidant/antiradicals and their role in our body and also their presence in spices and herbs. PDF

A differential pulse polarographic (DPP) method for the determination of Flumetralin is described based on the reduction of a nitro group at a dropping mercury electrode (DME) in Briton-Robinson buffers of pH 2.0 to 12.0 using 25% acetone-water mixture as a solvent. Also a cyclic voltammetric (CV) technique has been used to study the behaviour of Flumetralin at a hanging mercury drop electrode (HMDE). The DPP method described here has been applied to the analysis of Flumetralin in formulations, grains, soils and spiked water samples. Both standard addtion and calibration methods were used for the analytical measurements. The lower detection limit was found to be 1.87x10-8 M. PDF

Vasaka is a well-known herb in indigenous systems of medicine for its beneficial effects, particularly in bronchitis.Vasaka leaves, bark, the root bark, the fruit and flowers are useful in the removal of intestinal parasites. Vasaka herb is used for treating cold, cough, chronic bronchitis and asthma. The decoction of its root and bark in doses of 30 grams twice or thrice a day for 3 days can be given for this purpose. The juice of its fresh leaves can also be used in doses of a teaspoon thrice a day for days. In acute stages of bronchitis, vasaka gives unfailing relief, especially where the sputum is thick and sticky. It liquefies the sputum so that it is brought up more easily. For relief in asthma, the dried leaves should be smoked. In Ayurveda, a preparation made from vasaka flowers, known as gulkand is used to treat tuberculosis. The juice from its leaves should be given in doses of 2 to 4 grams in treating diarrhea and dysentery.A few fresh petals of vasaka flowers should be br...

Solid lipid nanoparticles (SLNs) introduced at the beginning of the 1990s represents an alternative carrier system to traditional colloidal carriers, such as emulsions, liposomes and polymeric micro and nanoparticles. A number of administration routes such as topical, oral, parenteral, nasal and pulmonary have been proposed for the delivery of SLNs. This paper reviews various production techniques for SLNs including their advantages and disadvantages, drug incorporation, loading capacity with the factors affecting drug incorporation and loading capacity and drug release, especially emphasizing on mechanism drug release. PDF