Journal of Chemical and Pharmaceutical Research

Abstract  The present work focuses on the development of hydrodynamically balanced delivery system of loratadine as a single unit floating capsules. Sustained release floating capsules for loratadine were fabricated using drug:polymer ratio of 1:4. The hydrocolloids were used in different proportions using 3 2 full factorial design and formulations were prepared. These formulations were optimized on the basis of buoyancy, matrix integrity, duration of floating and in vitrodrug release. All the nine formulations showed good buoyancy and matrix integrity. The duration of floating was more than 12 h for all formulations. In vitrodrug release study of these formulations indicated controlled release of loratadine and abot 90 percent drug was released at the end of 1 2 h.

Abstract  Indanone acetic acid is a non-heterocyclic fused ring of benzene with cyclopentananone moiety with acetic acid side chain in 1-position. This specific moiety has been synthesised and condensed with various substituents like PABA, piperidine, morpholine, benzimidazole, piperazine, pyrazolone and hydrazine to get the desired product for animicrobial screening by zone of inhibition study and MIC values with respect to some gram positive and gram negative microbes and fungal strains with reference standardantibiotics. The satisfactory result has beenfound in the antimicrobial and antifungal screening. 

Abstract  Two innovative, new, simple and low cost UV-spectrophotometric and first order derivative methods were developed and validated for estimationof Galantamine Hydrobromide in bulk drug and tablet dosage form. Galantamine Hydrobromide was estimated at 289 nm in Distilled Water. In first order derivative, it showed amplitude at 284.8 nm and λ minima = 290.4 nm with 286.4 nm as zero crossing point (ZCP). In both the methods linearity was found to be in the range of 20-100 μ g/ml; for UV spectrophotometric method (y = 0.007x - 0.002, r² = 0.999) and for first order derivative spectrophotometric method (Y=0.0012 x+0.00045; r2=0.999), respectively. These methods were analyzed and valiated for various validation parameters according to USP guidelines

Abstract Erythropoietin, or EPO, is a glycoprotein hormone that controls erythropoiesis , or red blood cell production. It is a cytokine for erythrocyte (red blood cell) precursors in the bone marrow. Also called hematopoietin or hemopoietin, it is producedby the peritubular capillary endothelial cells in the kidney, and is the hormone that regulates red blood cell production. The existence of a hormone that controls RBC production was first suggested by the experiments of Paul Carnot in 1906, who created anemic rabbits and then transfused their serum into recipient rabbits. EPO is produced by peritubular cells in the adult kidney, and in hepatocytes in the fetus. In adults, a small amount is also produced by the liver. The rate of Epo synthesis and secretion depends on local oxygen concentrations; hypoxia is the main stimulus for Epo production. Although the use of erythropoietin has been studied in critically ill patients, erythropoietin has not been shown to be effective in...

Abstract  Certain picric acid and paracetamol derivatives have been synthesized in good yields and tested against E. Coli, S.areus, B.subtillis, S.citrus for anti-microbial activity and tested against A.niger, C.albicans for anti-fungal activity. Characterization of new compounds has been done by means of spectral data and elemental analysis.