Journal of Chemical and Pharmaceutical Research

Abstract Bifunctional Pt/H-Beta and Pt/H-Mordenite catalysts were prepared by using incipient wetness impregnation method to obtain a 0.5 wt % metal load and applied to the Isomerization of n-hexane. Commercial Pt /H-Beta gave rise to a higher yield of high octane Dimethylbutanes (DMB) than the commercial Pt/H-Mordenite. To explain this result, both the dispersion and distribution of Pt clusters in the zeolite channels were investigated. The acidity and distribution of acid sites were examined by using ammonia and pyridine as probe molecules. Pt/H-Beta was found to be a potential catalyst for the Isomerization of n-hexane because Pt clusters could be well dispersed to give proper balance between metallic centres and acid sites in H-Beta zeolite although its acidity was low as compared to H-Mordenite.

Introduction   Prior to the initiation of method development , all the known information about the analyte such as its structure, physical and chemical properties, toxicity, purity, hygroscopicity, solubility, and stability should be determined. These data may be available from preformulation reports, early drug discovery sample screening reports, from the literature on similar compounds, or from past experience with similar compounds. However, many times this information is not available, so preventive measures must be taken in order to ensure that the analyte does not degrade or change during the method development scouting experiments. Implementation of a tray cooler, preparation of fresh samples, storage of samples in a refrigerator, and protection of the solids and sample solutions from light represent some common preventive measures.

Introduction Groundwater is ultimate, most suitable fresh water, resource with nearly balanced concentration of the salt for human consumption. Water is one the essential components for the sustenance of life on earth. Among the various source of water, ground water is considered to be the safe for drinking purposes. The water which is being used for industries, agriculture and human needs adds continuously contaminants to the ground water. Groundwater is used intensively for irrigation and industrial purposes, a variety of land and water-based human activities are causing pollution of this precious resource. Its over-exploitation is causing aquifer contamination in certain instances, people around the world are using ground water as a source of drinking water and even today, more than half of the world’s population depends on it for survival.

Abstract A simple, isocratic, rapid and sensitive high performance liquid chromatographic method has been developed for quantitative determination of Trazodone Hydrochloride and its three process related impurities. The method has been validated for the determination of related substances in Trazodone Hydrochloride using a C18, ODS (4.6mm×250mm×10μ m) column by keeping the flow rate of 1.5ml / min and having sensitivity of 0.2. The elution is carried out using a mobile phase consisting of methanol l80 ml, Acetonitrile 180 ml, Tetrahydrofuran 40 ml, and Trifluroacetic acid (0.5%) 600 ml. The detection isbeen carried out at 252 nm with injection volume of 10 μ L. The run time is 15 minutes for estimation of related substance. The precision, Linearity and accuracy of the method are demonstrated for Trazodone Hydrochloride. Specificity of the method is also been studied.

Abstract Furan ring systems are abundantly available in secondary plant metabolites . Due to their remarkable properties, many synthetic furans are utilized as pharmaceuticals. Hence a series of N-(furan-2-ylmethylene) benz- imines derivatives has been synthesized by reaction between furan-2--carboxaldehyde and various aromatic anilines to yield the schiff , s bases. The newly synthesized compounds showed potent CNS depressant and analgesic activities. Prior to determination of the Pharmacological activity LD 50 was determined. The pharmacological data obtained were tested for statistical significance.