Validation of Spectrophotometric Methods for Quanti tative Determination of 7-ADCA in Pharmaceutical Formulations

ABSTRACT
Two simple, sensitive and accurate methods are described for the determination of 7-Amino deacetoxy cephalosporanic acid (7-ADCA) in bulk drug and in formulations. Method M1&M2are based on the oxidizing reaction between 7-ADCA and Ninhydrin-Ascorbic acid (NIN-AA) (M1); β-Napthol-H2O2-Cupric nitrate-2, 4-DNP-Ammonium hydroxide (β-NPT,H2O2-DNP)(M2) solutions. The chromogen being extractable with chloroform could be measured quantitatively at 400 nm (M1) and 420 nm (M2).

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