Journal of Chemical and Pharmaceutical Research

ABSTRACT: The present work focuses on the development of hydrodynamically balanced delivery system of loratadine as a single unit floating capsules. Sustained release floating capsules for loratadine were fabricated using drug:polymer ratio of 1:4. The hydrocolloids were used in different proportions using 32 full factorial design and formulations were prepared. These formulations were optimized on the basis of buoyancy, matrix integrity, duration of floating and in vitro drug release. All the nine formulations showed good buoyancy and matrix integrity. The duration of floating was more than 12 h for all formulations. In vitro drug release study of these formulations indicated controlled release of loratadine and about 90 percent drug was released at the end of 12 h. Further details @ http://www.jocpr.com/ For more details @ http://www.jocpr.com/articles/formulation-and-invitro-evaluation-of-floating-capsules-ofloratadine.pdf

ABSTRACT: Two innovative, new, simple and low cost UV-spectrophotometric and first order derivative methods were developed and validated for estimation of Galantamine Hydrobromide in bulk drug and tablet dosage form. Galantamine Hydrobromide was estimated at 289 nm in Distilled Water. In first order derivative, it showed amplitude at 284.8 nm and λminima = 290.4 nm with 286.4 nm as zero crossing point (ZCP). In both the methods linearity was found to be in the range of 20-100 µg/ml; for UV spectrophotometric method (y = 0.007x - 0.002, r² = 0.999) and for first order derivative spectrophotometric method (Y=0.0012 x+0.00045; r2=0.999), respectively. These methods were analyzed and validated for various validation parameters according to USP guidelines. The quantitation limits were found to be 0.50 and 1.54 µg/ml, for UV-Spectrophotometric method and 3.3 and 10 µg/ml for the 1st order derivative method. The proposed methods were successfully applied for the determination of Galant...

ABSTRACT: Erythropoietin, or EPO, is a glycoprotein hormone that controls erythropoiesis, or red blood cell production. It is a cytokine for erythrocyte (red blood cell) precursors in the bone marrow. Also called hematopoietin or hemopoietin, it is produced by the peritubular capillary endothelial cells in the kidney, and is the hormone that regulates red blood cell production. The existence of a hormone that controls RBC production was first suggested by the experiments of Paul Carnot in 1906, who created anemic rabbits and then transfused their serum into recipient rabbits. EPO is produced by peritubular cells in the adult kidney, and in hepatocytes in the fetus. In adults, a small amount is also produced by the liver. The rate of Epo synthesis and secretion depends on local oxygen concentrations; hypoxia is the main stimulus for Epo production. Although the use of erythropoietin has been studied in critically ill patients, erythropoietin has not been shown to be effective in ...

ABSTRACT: In the present study, the wound-healing activity of some substituted hydroxytriazenes was investigated. Excision, resutured incision and dead space wound models were used to evaluate the wound-healing activity of substituted hydroxytriazenes. In excision wound model, treatment was continued till the complete healing of the wound, in incision and dead space wound models the treatment was continued for 10 days. For topical application, 5% w/w ointment of hydroxytriazenes was prepared in 2% sodium alginate and for oral administration hydroxytriazenes dissolved in DMSO, at dose 5 mg/kg were used. In excision and incision wound models, the control group of animals was left untreated and in dead space wound models the animals were treated with DMSO (1ml/kg). The healing of the wound was assessed by the rate of wound contraction, period of epithelialisation, skin breaking strength, granulation strength, dry granulation tissue weight and hydroxyproline estimation. Except the p...

ABSTRACT: A rapid, sensitive and specific RP-HPLC [1-5] method involving UV detection was developed and validated for determination and quantification of Lamivudine and Zidovudine. Chromatography was carried out on a pre-packed AltimaC18 5µ (150*4.6mm) column using filtered and degassed mixture of Ammonium acetate buffer:Methanol (80:20) as mobile phase at a flow rate of 1.0ml/min and effluent was monitored at 270nm. The method was validated in terms of linearity, precision, accuracy, and specificity, limit of quantification and limit of detection. The assay was linear over the concentration range of Lamivudine and Zidovudine was 37.5mcg-112.5mcg/ml and 75mcg to 225mcg/ml respectively. Accuracy of the method was determined through recovery studies by adding known quantities of standard drug to the pre analyzed test solution and was found to be 98.50%-99.9% and 98.30%- 100.10% within precision RSD of 0.71 and 0.82 for Lamivudine and Zidovudine respectively. The system suitability...

ABSTRACT: To study describe the actions of antipsychotics or neuroleptics on the behavioral effects elicited by ketamine on open-field, rota rod and tail suspension tests in mice. A series of novel analogs of 2-[3-{4-(3-chlorophenyl)-1-piperazinyl} propyl]-1,2,4-triazolo [4,3-a] pyridine-3- (2H)-one hydrochloride, a potential psychoactive drug of the piperazine and triazolopyridine chemical classes that has antidepressant, anxiolytic, and hypnotic properties were synthesized. Male swiss albino mice (25–30g) were used for the study and compounds were administered alone (0.1 or 0.2 mg/kg) or thirty minutes before ketamine (10 mg/Kg, ip). ketamine increased (63.3 ± 4.2) the locomotor activity compared to control, while neuroleptics decreased it (25.5 ± 4.2). Pretreatment with neuroleptics, in both doses, blocked hyperlocomotion caused by ketmine. Further details @ http://www.jocpr.com/ For more details @ http://www.jocpr.com/articles/studies-of-antipsychotic-drugs-as-pote...

ABSTRACT: A simple sensitive spectrophotometric method in UV region has been developed for the determination of Ceftazidime in bulk dosage form. The solution of ceftazidime in 0.1N HCl shows maximum absorbance at 261nm, beer’s law was obeyed in the concentration range of 2-10 µg ml-1. The absorbance was found to increase linearly with increasing concentration of ceftazidime, which is corroborated by the calculated correlation coefficient value of 0.9981. The slope and intercept of the equation of the regression line are 0.0465 and 0.0007 respectively. The analysis were validated statistically and its recovery studies result of percentage shows that the method was not affected by the presence of excepients which proves suitability of the developed method for the routine estimation of ceftazidime bulk and solid dosage form. This method were extended to pharmaceutical formulations and there no interference from excepients and diluents. The proposed methods are economical and sensit...