Journal of Chemical and Pharmaceutical Research

Abstract  In the present study, the wound-healing activity of some substituted hydroxytriazenes was investigated. Excision, resutured incision and deadspace wound models were used to evaluate the wound-healing activity of substituted hydroxytriazenes. In excision wound model, treatment was continued till the complete healing of the wound, in incision and dead space wound models the treatment was continued for 10 days. For topical application, 5% w/w ointment of hydroxytriazenes was prepared in 2% sodium alginate and for oral administration hydroxytriazenes dissolved in DMSO, at dose 5 mg/kgwere used. In excision and incision wound models, the control group of animals was leftuntreated and in dead space wound models the animals were treated with DMSO (1ml/kg). The healing of the wound was assessed by the rate of wound contraction, period of epithelialisation, skin breaking strength, granulation strength, dry granulation tissue weight and hydroxyproline estimation. Except t...

Abstract  Two simple and sensitive visible spectrophotometric methods (A and B) have been developed for the quantitative estimation of sparfloxacin, inbulk drug and pharmaceutical dosage forms. Methods were based on the formation of coloured chromogens, which were measured at 549 nm and 465 nm, respectively. The results obtained withthe proposed methods are in satisfactory with the labeled amounts when tablet dosage forms were analysed

Abstract Emulsions are widely used as medicinal and cosmetic delivery systems on account of general observations that emulsified materials normally possess the properties being exhibited by its bulk components. In order to widen scope of application of the conclusions drawn, o/w emulsions covering almost all routes of administration were considered for the study. These included parenteral emulsion, oral Emulsion and topical emulsion. Zeta potential including zeta deviation and peak position, and effective particle size of the emulsions including Z-average diameter, poly dispersity index and peak position were studied using a Zeta sizer (Malvern instrument). Employing Laser Doppler Electrophoresis and dynamiclight scattering technique, Zeta potential and particle size distribution of the droplet as a function of time can be determined, which was done in this paper. Zeta potential is used to studythe chemistry involved in determining whether or not an emulsion will remain stabl...

Abstract In present study a series of chalcones of anilide and their corresponding product 1-[(4,5-dihydro-5-phenyl-3-(phenylamino)pyrazol-1-yl)]ethanone derivatives I-VI were synthesized and evaluated for their anticonvulsant activity againstelectric shock induced convulsion method in rat at a dose of 125 mg/kg and 250 mg/kg intra peritonially. The structures of compounds were confirmed by IR, H 1 NMR and Mass spectroscopy. The compounds of this series (III) and (V) were found to be most potent, which have shown higher percent of anti convulsant activity. Phenytoin was taken as reference drug. Their pharmacophoric groups are similar and the possible structure of suitable fused heterocyclic could be accepted to give anti convulsant activity

Abstract  Quinazolinone and their derivatives have been studied extensively for various biological activities such as anti-inflammatory, antimicrobial, antitumor, antioxidant and anti-HIV activity. Schiff bases have also been exploited extensively for antimicrobial and antioxidant activities. In the present investigation various quinazolinone amines have been clubbed with five membered heterocyclic aldehydes to obtain the title compounds. All the synthesized compounds have been screened for their antibacterial activity against S.aureus, B.subtilis, E.coli and K.pneumoniaand invitroantioxidant activity by 1,1-diphenyl-2,2-picryl hydrazyl free radical (DPPH) method.