Journal of Chemical and Pharmaceutical Research

ABSTRACT: Major depressive disorder (MDD) is a debilitating disease worldwide and occurs with a high prevalence in elderly individuals. In attempt to search for herbal medicine with antidepressant effect, each in vitro model must be properly validated. The objective of this study was to determine the effect of Senna siamea Lam. (Cassod tree) leaf extracts prepared using ethanol and water on activity of DAT, NET, SERT and total MATs in in vitro model, human neuroblastoma LAN-5 cell line using a commercial neurotransmitter transporter reuptake assay kit. After measuring the intracellular fluorescence, we calculated RFU area below curve reflecting the activity of dopamine transporter (DAT), norepinephrine transporter (NET), serotonin transporter (SERT) and all monoamine neurotransmitter transporters (MATs) in LAN-5 cells after treatment for 30 min with 25 and 100 µg/mL of Senna siamea Lam. leaf extracts in the absence or presence of combining antidepressants. We observed the fluoresc...

ABSTRACT: This work investigated the generation of activated carbon from melon seed husk - a low value agricultural waste, its characterization using volumetric methods and subsequent utility in the bleaching of vegetable oil. The production of activated carbon from melon seed husk was done by a chemical activating process involving the use of 1 M NaOH solution mixed with 20 g of the sample and steeped overnight. The steeped waste was filtered and air-dried and then carbonized in a muffle furnace at the temperature of 500oC for a residence time of 40 minutes to give an activated carbon. The resultant activated carbon in powder form was characterized for the particle size, pH, bulk density, iodine adsorption number, pore volume, porosity and moisture content. The activated carbon was equally applied for the bleaching of de-gummed sample of vegetable oil. The result of the characterization showed that the powdered activated carbon has good properties and compared favourably with oth...

ABSTRACT: In order to improve the activity of laccase by Trametes versicolor FG-97, response surface methodology was applied to optimize the fermentation conditions. We first optimized the conditions by using Plackett-Burman design to screen for the significant factors, found that pH, temperature and incubation time were the main ones. After the steepest ascent test and Box-Behnken design, the optimum conditions for laccase production were found to be a temperature of 30 °C, pH of 5.2 , time of fermentation for 9 days (160r/min) and 2% (w/v) of inoculation density, the peak of laccase activity achieved at 306.33 U·L-1 ， and the experimental values agreed with the predicted values. These results suggested that the predicted model was reliable and available for the optimization of laccase fermentation conditions. Further details @ http://www.jocpr.com/ For more details to visit :  http://www.jocpr.com/articles/optimization-of-fermentation-conditions-by-trametes-versicolor-f...

ABSTRACT:   Indanol is most stable molecule it’s stabilized by internal hydrogen bonding, which exists between the hydroxyl hydrogen and the π–cloud of the benzene ring. A comprehensive ab initio calculation using the DFT/ 6-31+G (d) level theory showed that 2-bromo1-Indanol can exist in eight possible conformations, which can interchange through the OH group on the five-membered ring. Density functional theory calculations were used to predict the vibrational frequencies and to help in normal mode assignments. The spectral intensities indicate that, at 90°C, 82% of the molecules exist in its most stable form with the intramolecular hydrogen bonding. Furthermore, a natural bond orbitial analysis was performed describing each hydrogen bond as donor-accepter interaction. The Fourier transform infrared spectra (4000–400 cm−1 ) and the Fourier transform Raman spectra (3500–100 cm −1 ) of the title molecule in the solid space have been recorded. The calculated HOMO and LUMO energie...

ABSTRACT:   In the present study, macroelements (Na, K, Ca, Mg and P) and trace elements (Fe, Zn, Cu Mn, Cr and Ni) content of fresh and cooked vegetables of twenty one wild vegetables traditionally consumed in North-East India were examined. All the examined vegetables are found to be rich source of macroelements as well as trace minerals. Calcium is the most abundant macroelement ranging from 125.7 mg/100g to 543.2 mg/100g. Cooking significantly (p<0.05) decreases the level of potassium, magnesium, phosphorous and calcium in most of vegetables. Iron is the most abundant microelement in the examined vegetables which ranged between 6.97 mg/100g to 22.73 mg/100g. Cooking has no significant (p>0.05) effect on the trace elements of most of vegetables. Further details @ http://www.jocpr.com/ For more details to visit :  http://www.jocpr.com/articles/mineral-content-of-some-wild-green-leafy-vegetables-of-northeast-india.pdf

ABSTRACT: Ontology is a model for knowledge storing and representation, which abstracts certain application field of the real world into a set of concepts and relationships among concepts. Hence, ontology is often used in information retrieval and search expanding. By virtue of its powerful usage, ontology similarity computation has widely used in medical science, biology science and chemical science(see Lambrix and Edberg2003, Mork and Bernstein 2004,Su andGulla 2004, and Guet al., 2004 for examples). As ontology used in chemical science and biology science, every vertex can be regard as a concept of ontology, measure the similarity of vertices using the information of ontology graph. Let G be an ontology graph corresponding to ontology O, the goal of ontology similarity measure is to find a similarity function Sim: V×V → +   ∪ {0}which maps each pair of vertices to a real number. A populartechnology to yield optimal similarity between vertices on ontology is using a score ...

ABSTRACT: Wardha, Wainganga and Penganga are the major rivers surrounding Chandrapur district. Wardha river flows into the district from western boundary and then flows along the boundaries of Warora, Chandrapur, Korpana, Rajura, Ballarpur and Gondpipari talukas and Penganga and Irai rivers meet the Wardhariver during this course. As Wardha river flows through several industrial active areas of Chandrapur district monitoring of water quality of Wardha river was carried out during September 2011 to August 2012 period to assess the water pollution level. Two sampling stations were selected at downstream of Chandrapur city. Whereas one sampling station upstream were selected .Water samples were collected and analyzed as per standard methods. Parameters such as pH, turbidity were measured in situ during the sampling. Higher values of several physico-chemical parameters indicate the pollution of riverine ecosystem in the study area. Domestic wastes, municipal sewage, industrial efflu...

ABSTRACT: The piece of investigation was carried out to study the surface water quality and physico-chemical characteristics of Hindusthan lalpeth open cast coal mines surface water Chandrapur district,(M.S),.during the period of nine months containing Rainy, winter and Summer Season.(Nov 11 to july 12). Chandrapur district is located in the eastern edge of Maharashtra in Nagpur Division .The coal mining industry has to dispose of millions of litres of water every day to excavate coal from mine . This water is the main source of various water supplies in the thickly populated coal field and general use. Chandrapur city is surrounded by many major and minor industries. In this study, water samples from Hindusthan Lalpeth open cast coal mine were collected and analyzed. Attempt to reflect the impact of mining on surrounding water quality of these areas. Various physico-chemical characteristics of the mine water were analyzed with respect to different parameters like Temperature, P...

ABSTRACT: A simple and precise first order derivative and area under curve [AUC] UV- spectrophotometric methods have been developed and validated for the estimation of oxolamine citrate in bulk and its tablet formulation. The standard and sample solutions of oxolamine citrate were prepared in distilled water. Oxolamine citrate was estimated at 229.2 nm for the first order derivative UV-spectrophotometric method (A), while in area under curve (AUC) method (B) the zero order spectrum of oxolamine citrate was measured in between 228.6 nm to 246.4 nm. Beer’s law was obeyed in the concentration range of 1 to 14 µg / ml with coefficient of correlation value 0.9991 for first order derivative method. Similarly in AUC method, Beer’s law was obeyed in the concentration range of 1 to 14 µg / ml with coefficient of correlation value 0.9999. These methods were tested and validated for various parameters according to ICH guidelines. The precision expressed as relative standard deviation, whic...

ABSTRACT: In the present study UV-Spectrophotometry and RP-HPLC methods were validated for the simultaneous analysis of acetaminophen in marketed tablets. The methods were validated in terms of linearity, sensitivity (Detection limit and Quantification limit) accuracy (% Recovery), precision (inter day, intraday and reproducibility). Both the methods were linear (r2 = 0.9993 for UV method and 0.9995 for HPLC) and accurate (% recovery was 99.48 % - 101.42 % for UV method and 101.85 % - 102.35 % for HPLC method). The detection limit and quantification limit were 0.192 µg/ml and 0.640 µg/ml for UV method and 0.0155 µg/ml and 0.0518 µg/ml. The method was also found precise (% RSD < 5%) and robust. Assay of five marketed brands of paracetamol were determined by both the methods and no statistically significant difference was noticed between the assay obtained from UV-Spectrophotometry and RPHPLC methods by paired t - test at 5 % significance level. The results obtained from the me...

ABSTRACT: Use of plant based drugs and chemicals for curing various ailments and personal adornment is as old as human civilization. Plants and plant-based medicaments are the basis of many of the modern pharmaceuticals we use today for our various ailments. Cinnamon has a long history both as a spice and as a medicine. In the present study, an attempt was made to determine the phytochemical composition and in vitro effects of methanolic extract of Cinnamomum cassia bark against Candida parapsilosis SN 1980, Candida guilliermondii SN 2006 and Candida glabrata SN 2266. Preliminary phytochemical analysis revealed the presence of phenols, alkaloids, steroids and tannins in varying concentration. In GC-MS analysis, the major compounds were cinnamaldehyde, p-methoxy cinnamaldehyde, cis-2-methoxy cinnamic acid and cinnamic acid. Biological examination was carried out in terms of minimum inhibitory concentration; filter disc assay and growth curve study. SEM examination of treated cell...

ABSTRACT: The densities were measured over the entire molefraction range for the binary liquid mixtures of Cyclohexanol with 2-Nitrotoluene & 3- Nitrotoluene at four different temperatures (303.15 K, 308.15 K, 313.15 K, 318.15 K). From the experimental data, excess molar volumes ( ) E Vm values were calculated. These values are negative for Cyclohexanol + 2-Nitrotoluene and positive for Cyclohexanol + 3-Nitrotoluene. The excess molar volumes ( ) E Vm values are analysed on the basis of molecular interactions between unlike non-electrolyte molecules. Further details to visit : http://www.jocpr.com/ For more details visit:  http://www.jocpr.com/articles/molecular-interactions-in-nonelectrolyte-binary-liquid-mixtures-of-cyclohexanol-with-2nitrotoluene-and-3nitrotoluene-at.pdf

ABSTRACT: In ancient to modern system of medicine Curculigo species has been recommended for relief of different central nervous system disorders. Under this reserach study the hexane, dichloromethane, ethyl acetate, methanolic and water extracts of Curculigo orchioides root were evaluated for anxiolytic activity using Elevated Plus Maze model (EPM) and Light Dark model (LDM) in mice. The methanolic and aqueous extract exhibited potential anxiolytic effects at 400 mg/kg., p.o. in both methods whereas hexane, dichloromethane and ethyl acetate extract were less effective. Preliminary phytochemical studies of the extracts revealed the presence of flavanoids, tannins and phenolic compounds that may contribute to the anxiolytic activity of Curculigo orchioides. Further details to visit : http://www.jocpr.com/ For more details visit:  http://www.jocpr.com/articles/anxiolytic-effect-of-curculigo-orchioides-on-the-elevated-plus-maze-and-lightdark-model.pdf

ABSTRACT: Semantic similarity is the essential part of automatic question answering system, and the computation of semantic similarity based on ontology can provide more various semantic information compared with the traditional method. In this paper, we firstly propose a semantic similarity algorithm used in the sentence similarity computation, combining relations of semantics, hierarchical structure and depth. Next, based on conventional sentence similarity algorithm, we develop a weighted sentence similarity algorithm. Finally, a question answering system is implemented with the two proposed algorithms. The experimental results show that our proposed method can achieve higher accuracy than others. Further details to visit : http://www.jocpr.com/ For more details visit:  http://www.jocpr.com/articles/a-computation-study-on-semantics-based-weighted-sentence-similarity.pdf

ABSTRACT: We employed microfluid technique to synthesize ethyl vanillin by using microfluid technique. The structure of obtained ethyl vanillin was characterized by FTIR. The conditions of reaction temperature, flow velocity and the amount of raw materials were investigated and optimized to produce ethyl vanillin with high yield. The optimized experimental results indicated that using o-ethoxyphenol and chloroform as the main raw materials in the presence of phase-transfer catalyst of triethylamine will induce the Reimer-Tiemann reaction to form ethyl vanillin. The molar ratio was o-ethoxyphenol: chloroform: sodium hydroxide: triethylamine = 1:1.2:4.0:0.025, reaction temperature was 55 ℃ and flow rate was 6 mL/min. Results revealed that this method had features of short technological process and convenient manipulation. Under the optimal conditions, the yield ratio of ethyl vanillin was up to 82.3%. Further details to visit : http://www.jocpr.com/ For more details v...

ABSTRACT: Plants or plant based products have been used in the traditional healthcare system from time immemorial for treatment of various diseases; wound healing is one among them. The aim of present study is to understand the 2, 5- dihydroxy-3-undecyl-1, 4-benzoquinone (Embelin) and dimeric form of embelin (Vilangin) mediated attenuation of wound healing and cell migration at the cellular level. We used fibroblast cell based model for studying cytotoxicity, wound healing and Boyden’s chamber migration assay. In addition to this, effect of cell migration of both embelin and vilangin was studied at the single cell level using live cell imaging technique. Results, shown that the concentration required for 50% cyotoxicity (IC50) towards human dermal fibroblast cells was determined as 32 ± 1 µg/ml & 15 ± 2 µg/ml for embelin and vilangin respectively. Furthermore 0.1 and 1.0 µg/ml concentration were chosen for further wound healing and migration studies. Results demonstrate that...

ABSTRACT: The measurements of ultrasonic velocity (υ), density (ρ) and viscosity (η) of the binary liquid mixture of N, NDimethyle acetamide and Benzonitrile of pure and binary mixture for the entire range of compositions at temperature 308 K have been carried out. The experimental data of these mixtures is used to evaluate other thermo dynamical parameters with their excess values such as compressibility (βα), molecular free length (Lf), acoustic impedance (Z), free volume (Vf), internal pressure (πi) and the excess values as excess compressibility βα E , free length Lf E , acoustical impedance ZE , free volume Vf E and internal pressure πi E . From the nature of these excess parameters the nature and strength of the interactions in these binary systems are discussed in view of molecular interaction. The non linearity observed in the plots of these ultrasonic parameters and their excess values with the composition range indicates presence of the intermolecular interaction betwe...

ABSTRACT: chemically described as N2 -acetyl-N-benzyl-D-homoserinamide used for the treatment of . It can also be prescribed off-label to treat conditions such as diabetic neuropathic pain. It enhances slow inactivation of voltage-gated sodium channels, resulting in stabilization of hyper excitable neuronal repetitive neuronal firing. analytical methods [2-10] have been reported for the estimation of , accurate and stability indicating reversed-phase HPLC method lacosamide in pharmaceutical dosage form as per ICH Figure 1: Chemical structure of lacosamide EXPERIMENTAL SECTION out on Waters HPLC system (2695 module) equipped with module) with auto sampler and running on Waters Empower software. The column used is Kromasil C Journal of Chemical and Pharmaceutical Research, 2013, 5(11):732-739 ISSN : 0975-7384 CODEN(USA) : JCPRC5 method for the estimation of lacosamide in and Ajaya Kumar Patnaik3 Vizianagaram, A.P, India ences, Berhampur, Orissa, India versity, Cuttack, Orissa, Ind...

ABSTRACT: In the present study, water quality Index (WQI) calculated and intended of the water bodies to ascertain the quality of water for public health in Bilari town of Moradabad district, Uttar Pradesh, India. This study deals the influence of environmental parameters of water quality of different water bodies. There are many ways to evaluate the quality of water as deemed fit for drinking and irrigation purpose. WQI indicating the water quality in terms of index number which offers a useful representation of overall quality of water for public use or for any other intended applications. A number of parameters affect the usability of water source for particular purpose. In this study water quality index is determined on the basis of various physico-chemical parameters. From the foregoing observation of the physico-chemical parameters, it may be concluded that the water bodies show the characters of eutrophication. Further details to visit : http://www.jocpr.com/ For ...

ABSTRACT: A series of new metal complexes Cr+3, Fe+3,Ni+2,Co+2, and Cu+2, with dye ligand derived from 2- aminobenzothiazole have been prepared and fully characterized on the basic of microelement analysis, atomic Absorption, 1HNMR, FT-IR, UV-visible spectra techniques as well as the magnetic moment of solid complexes and molars conductance. The results abstained from (C.H.N.M) analysis and spectral measurements investigated all complexes are octaherdral geometries in the formula [ML2(H2O)2]X, where M = Co+2, and Cu+2, X = Cl-1 for Cr+3 and Fe+3 except [NiL2]Cl2 which was square planer. The biological activity of the ligand and their complexes were studied against selected types of bacterial and fungal which included Staphylococcus, Klebsiella, Serratia marcescens and Pseudomonas aeruginosa. Further details to visi t: http://www.jocpr.com/ For more details visit:  http://www.jocpr.com/articles/synthesis-and-biological-activity-study-of-14567tetrahydro13benzothiazol2y...

ABSTRACT : The study approach of RCC(roller compacted concrete) autogenously volume deformation complexity based on the de-noising of wavelet transform from symbolic dynamics viewpoint is present in the paper. First, the deformation sequences are de-noised by the wavelet transform and the noise is filtered. Then the complexity of deformation is calculated with the Lempel-Ziv algorithm. Finally the complexity of RCC volume deformation is quantitatively analyzed in the practical engineering, and a new tool is provided to study the complexity of concrete system. The results are as following: (1) the complexity with wavelet de-noising is less than original sequence and has evident law. (2) the deformation complexity of high volume fly-ash slag RCC is markedly larger than that of RCC mixed with MgO.(3) the deformation complexity of early age RCC is higher than that of 180d. (4) The complexity is greater along with the higher temperature. (5) The deformation complexity of RCC mixed wi...

ABSTRACT : Researches on the dynamic properties and vibration modes identification of Printed Circuit Board(PCB)loaded on train are important for the train safety in transportation. In this paper, a novel approach to identify the vibration modes of PCB is presented. The free acceleration response of the PCB is expressed as the sum of linear exponentials, the zeros and residues of the free response are identified by the Prony method, the zeros and residues are optimized by the nonlinear total least 1-norm method. An experiment system is formulated to record the free response of PCB, the zeros and residues are identified and optimized, the simulation results indicate the approach presented in this paper is accurate to identify the PCB vibration modes. The algorithm presented in this paper is more robust and more accurate to identify PCB vibration modes. The technique in this paper is useful for PCB design and the safety management of train. Further details for more Article...

ABSTRACT : A validated specific stability indicating reversed-phase liquid chromatographic method was developed for the quantitative determination of Aripiprazole and its related substances in bulk samples, pharmaceutical dosage forms in presence of degradation products. Forced degradation studies were performed on bulk sample of Aripiprazole as per ICH prescribed stress conditions using acid, base, oxidative, thermal stress and photolytic degradation to show the stability indicating power of the method. Significant degradation was observed during basic stress and no degradation was observed in other stress conditions. The chromatographic method was optimized using the samples generated from forced degradation studies and the impurity spiked with Aripiprazole. Good resolution between the peaks corresponds to impuritiy-1, degradation products from the analyte were achieved on YMC PACK C18 column using the mobile phase consists a mixture of Sodium dihydrogen Orthophosphate dehydra...

ABSTRACT : GC-MS analysis was carried out for the identification of the phytochemicals present in the methanolic leaf extract of .Nothapodytes nimmoniana. It indicates that the leaf extract is rich in phenolics, fatty acids, flavonoids and antioxidants. GC-MS analysis of methanol extract to identification of 26 compounds. The main compounds, were 9,12,15-Octadecatrienoic acid, [Z,Z,Z] is a compound name Linolenic acid used for Antiinflammatory, antiarthritic, anticoronary and anticancer,etc. Further details for more Articles: http://www.jocpr.com/ For more details to visit Full Text URL:  http://www.jocpr.com/articles/gcms-analysis-of-nothapodytes-nimmoniana-j-graham-mabberly-leaves.pdf

ABSTRACT : Based on the characteristics of solid magnetic abrasive and abrasive flow finishing, a new technology of viscoelastic magnetic abrasive finishing is presented. The theoretical micro model of viscoelastic magnetic abrasive tools is established, and influencing factors of a positive pressure are determined by force analysis. Finishing mechanism of micro-grinding, slipping, rolling and so on is analyzed theoretically and verifying experimentally. Experiments also show that all burrs are removed, the edges are rounded off and the surface is smooth, the surface roughness value Ra of hole surface drops from 0.53μm to 0.05μm. Its successful application will effectively solve the practical difficulty of deburring and surface finishing for special shapes such as groove, keyway, etc., and fulfil the quantitative finishing of complex surfaces. Results can provide the theoretical basis for the preparation of viscoelastic magnetic abrasive and further experimental study of this pr...

ABSTRACT: The objective of this paper is to obtain the developing tendency of outcrop coal fire under the multi-ventilation powers and fire pressure, so as to provide technical support for the governance of the fire area and ensuring mine work safety. The structural characteristic of the thermal dynamic system of outcrop coal fire under the control of multi-ventilation power factors have been analyzed and the practical application has been carried out. The thermal dynamic system of the outcrop coal fire under the control of multi-ventilation power factors include five sub-systems, namely combustion, heat dissipation of coal and rock, gas seepage and oxygen supply, gas discharge, and goaf leakage. Then, the mathematical model of the thermal dynamic system is set up and is applied in the old Shaft II fire area of Didao coalmine. At last, the changes of combustion product concentration, pressure and seepage velocity in the outcrop, which is under the condition of the even air press...

ABSTRACT: An extractive colorimetric method has been developed for estimation of Oxybutynin chloride in its tablet form. Bromothymol blue indicator was used as the coloring agent, and a straw yellow color solution was formed in the presence of acidic medium after extracting the drug with chloroform. The solution absorbance was measured at 414 nm. The linearity range was in the range of 2.5-12.5 µg/ml. The validation of the new proposed method was carried out on various parameters like linearity, accuracy, precision, selectivity, specificity, robustness, and ruggedness, LOD, LOQ. Further details to visit: http://www.jocpr.com/ For more details PDF Link:  http://www.jocpr.com/articles/development-and-validation-of-new-colorimetric-method-for-the-estimation-ofoxybutynin-chloride-in-bulk-and-dosage-form.pdf

ABSTRACT: Butanamide derivative (1) coupls smoothly with arenediazonium salts to afford the hydrazone (3). The latter product reacts with dimethylformamide – dimethylacetal (DMF-DMA) and or malononitrile to afford the substituted 1,4- dihydropyridazines (5,6). Several new pyran (8), thiophene (9), pyrazole (14) and isothiocyanate derivatives (17,18) have been synthesized by the reactions of butanamide with 4-chloro-benzylidenemalonitrile, malononitrile and elemental sulfur, and hydrazine hydrate respectively. Refluxing of butanamide (1) with p-chlorobenzaldhyde afforded compound (10). Treating butanamide derivative (1) with (DMF-DMA) afforded compound (11) and when reacting with triethylorthoformate and hydroxylamine hydrochloride afforded compounds (13, 15). Treating of sulfonamide with thiophosgene afforded isothiocyanate product (16) which on refluxing with p-toulidine or methanol afforded compounds (17, 18) respectively. Further details to visit: http://www.jocpr.com/ ...

ABSTRACT: An approach for quantitative estimation of Mefloquin Hcl in formulation in presence of its degradation products. The method has shown adequate separation for Mefloquin Hcl from their associated main related compound and their degradation products. Separation was achieved on a Waters Symmetry, C18, 250 mm × 4.6 mm, 5 µ ,column at 25°C temperature by using a mobile phase consisting Buffer– Methanol ( 25:75 v/v ) [Buffer: sodium hydrogen sulphate monohydrate in 1000 ml of water] at a flow rate of 0.7 ml/min, and UV detection at 280 nm. In the present study, comprehensive stress testing of Mefloquin Hcl was carried out according to ICH guideline Q1A (R2). The specificity of the method was determined by assessing interference from the placebo and by stress testing of the drug (forced degradation). Drug was subjected to Acid hydrolysis, Alkali hydrolysis, Oxidation, Dry heat and Photolysis to apply stress conditions. There were no other coeluting, interfering peaks from exci...

ABSTRACT: Schiff base derived from 2-hydroxy-5-chloroacetophenone and 2-amino-4-phenyl thiazole with Complexes of Co(II), Ni(II), Cu(II) and Zn(II) have been synthesized and characterized on the basis of elemental analysis, Infrared, 1H NMR, molar conductance and magnetic susceptibilities analysis. The Schiff base acts as a monobasic bidentate ligand commonly coordinates through the oxygen atom of phenolic OH group and the nitrogen atom of azomethine group, which is confirmed by IR spectral data. All the complexes have been evaluated for their antimicrobial activity by agar cup-plate method against various organisms. Further details to visit: http://www.jocpr.com/ For more details to PDF Link:  http://www.jocpr.com/articles/synthesis-and-microbial-evolution-of-coii-niii-cuii-and-znii-complexes-of-bidentate-schiff-base-derived-from-2amino4phen.pdf

ABSTRACT: Ternary complexes of Copper (II) with different amino acids have been prepared, in which proline taken as a common ligand and valine or threonine taken as secondary ligand. Amino acids have the tendency to form complexes with different metals and have important significance in biological and pharmaceutical fields. The complexes have been characterized by elemental analysis, magnetic measurement, thermal analysis, ESR, IR, XRD spectral studies. A distorted octahedral structure has been proposed for all the prepared complexes. Further details to visit: http://www.jocpr.com/ For more details to PDF Link:  http://www.jocpr.com/articles/spectroscopic-and-thermal-studies-of-copper-ii-complexes-with-different-amino-acid.pdf

ABSTRACT: Acoustic study of Atropine sulphate water binary mixture is carried out at 35oCand the data’s are correlated using Concentration, Density, Ultrasonic velocity, Acoustic Impedance, Free length, Adiabatic compressibility and Relaxation time. The data reveal the molecular interaction of atropine-water molecule system. Further details to visit: http://www.jocpr.com/ For more details to PDF Link:  http://www.jocpr.com/articles/acoustic-study-of-atropine-sulphate-in-water-of-various-concentrations-at-35ocusing-ultrasonic-interferometer.pdf

ABSTRACT: Copper (II) and Iron (III) complexes of Schiff base ligand namely (Z)-3-hydroxy-4-((5-methylthiophen-2-yl) methyleneamino) benzoic acid derived from the condensation of 5-methyl-2-thiophene carboxaldehyde with 4- amino-3-hydroxy benzoic acid were synthesized. The Schiff base and its metal complexes were structurally characterized based on elemental analysis, molar conductance, IR, UV-Visible and EPR spectral and thermal (TGDTA) analyses. The FTIR spectra showed that the ligand is coordinated to the metal ions in a tridentate manner through azomethine nitrogen, thiophene sulphur and phenolic OH groups. The molar conductance measurements of the complexes in DMF showed non-electrolytic nature. From the EPR spectra an octahedral geometry has been proposed for Cu(II) complex. The synthesized Schiff base ligand and its metal complexes were screened for their biological activity against bacterial species, two Gram –ve bacteria (Escherichia coli, Enterobacter aerogenes) and on...

ABSTRACT: Cr(VI) is a contaminant in various resources that is used by man in daily life, for e.g. soil ground water, river water, vegetables grown in such soil etc. it is a heavy metal, consumption of which might cause fatality to the consumer. It is seen that iron nanoparticles are able to reduce this Cr(VI) to its trivalent ion Cr(III) which is much less harmful. This article deals with the use of Iron Nanoparticles biosynthesized from green tea (GT) for its possible application in reducing toxicity and pollution caused by Cr(VI). The method used is a batch method where we get a number of similarly proceeding reaction which do not interfere with each other. The decrease in concentration of the standard solution of K2Cr2O7on addition of iron nanoparticles is used as an indicator of reduction of Cr(VI) to Cr(III). It is seen that the GT Fe-NPs remove Cr(VI) from the solution with good efficiency and may have good future prospects as an antipollution measure. Further detail...

ABSTRACT: There is now an expansion of interest in phytochemicals as a new source of natural antioxidants to be used in foods and pharmaceutical preparations to substitute synthetic antioxidants, which are being restricted due to their potential health risks and toxicity. Eight Libyan medicinal plants belonging to different families were extracted successively with three solvents of different polarities using microwave technique. The antioxidant activity of these plant extracts were evaluated using 2,2, Diphenyl-1-picryhydrazyl (DPPH) radical scavenging method. Among the twenty four crude extracts, six showed strong antioxidant activity (IC50 ranging between 4.55 to 21.55 µg/ml), six of the extracts exhibited moderate antioxidant activity (IC50 values ranged between 40.7 to 94.4 µg/ml), and four crude extracts exhibited weak antioxidant activity (IC50 more than 200 µg/ml). The IC50 values of quercetin and ascorbic acid, used as standards in this assay were found to be 3.35 and ...

ABSTRACT: Study 3D-QSAR is applied to a set of 57 molecules based on N-phenylsuccinimides using the principal component analysis (PCA) method, the multiple linear regression method (MLR) and the artificial neural network (ANN). The predicted values of activities are in good agreement with the experimental results. The artificial neural network (ANN) techniques, considering the relevant descriptors obtained from the MLR, showed a correlation coefficient of 0,9 with an 8-20-1 ANN model which is a good result. As a result of quantitative structure-activity relationships, we found that the model proposed in this study is constituted of major descriptors used to describe these molecules. The obtained results suggested that proposed combination of several calculated parameters could be useful in predicting biological activity of N-phenylsuccinimides derivatives. Further details to visit : http://www.jocpr.com/ For more details PDF Link:  http://www.jocpr.com/articles/com...

ABSTRACT: Terpolymeric ligand (m-CMF-II) was synthesized by acid catalysed polycondensation of m-cresol (0.1 M), melamine (0.05 M) and formaldehyde (0.2 M) at 120-1250C. Tentative structure of ligand was determined by physicochemical methods such as elemental analysis, IR and NMR. Activation energy of electrical conduction was determined by voltage divider method. Ligand was found to obey Wilson’s law. Thermokinetic parameters of thermal degradation were determined by Freeman-Carroll (FC) and Sharp-Wentworth (SW) method. Thermokinetic parameters such as activation energy (Ea), apparent entropy (∆S), free energy (∆G) determine by both methods were in good agreement. Degradation was found to be first order. Further details to visit : http://www.jocpr.com/ For more details PDF Link:  http://www.jocpr.com/articles/electrical-conductance-and-thermokinetic-parameters-of-newly-synthesized-terpolymeric-ligands.pdf

ABSTRACT: Downhole oil-water separation and reinjection technology can effectively solve the problem that the moisture of produced fluid is getting higher and higher, and as a key component of the injection-production system, injection-production string withstands packer's seating axial force, internal pressure, external pressure of oil and multi-load conditions, thereby resulting in the bending deformation of oil tube, and then causing the systems running eccentric wear, cards pumps and other phenomena. In this paper, the deformation of oil pipe between the injection-production system packers were mechanical simulation analyzed, and obtained the effective measures to reduce pipes bending deformation, to guarantee efficient and safe operation of the pipe, and then the injection-production system can run smoothly for a long time. Further details to visit : http://www.jocpr.com/ For more details PDF Link:  http://www.jocpr.com/articles/simulation-analysis-of-the-oil-...

ABSTRACT: Anodization of Zircaloy-4 in EDTA electrolyte has been studied under different anodizing conditions at room temperature. It has been observed that the change of current density and solvent has a marked influence on the kinetics of anodization. The kinetic parameters like rate of formation(dV/dt), ionic current efficiency(Ƞ) and differential field of formation(FD) were calculated. The surface natures of the anodized films were studied from Scanning Electron Micrographs(SEM) under different anodizing conditions. Further details to visit: http://www.jocpr.com/ For more details PDF Link:  http://www.jocpr.com/articles/effect-of-conditions-on-the-anodization-of-zircaloy4-in-edta.pdf

ABSTRACT: Polycarpaea corymbosa are widely used traditional medicinal plant to treat various ailments. The antimicrobial potential of Polycarpaea corymbosa against human pathogenic microorganisms (fifteen bacteria and six fungus) ware investigated. Antimicrobial activity of various plants extracts was compared with commercially available antibiotics. The antimicrobial potential of the above plant extracts was seen against the test organism using disc diffusion method. The phytochemical prospection of the dried aerial and root extracts showed the presence of different classes of secondary metabolites, as phenols, flavonoid, alkaloids and tannins that have demonstrated antimicrobial action. Acetone and methanolic extracts showed considerably good antibacterial activity against all bacteria and fungi. This study shed the light on the ability of extracts from the plant to combat pathogens which will help as natural antimicrobial agents as well as can be used in pharmaceutical and fo...

ABSTRACT: The binary complexes of metal ions Fe+3,Co2+,Ni2+,Cu2+,Zn2+,Cd2+ with 3,5 Dinitrosalicylic acid as a ligand were studied in aqueous media using Irving Rosotti method. Acidity constant and stability constant were studied at 270C at ionic strength 1N NaNo3. Stability constants calculated by half integral method and point wise method were compared and found to follow Irving and Williams rule. Further details to visit: http://www.jocpr.com/ For more details PDF Link:  http://www.jocpr.com/articles/potentiometric-studies-of-binary-complexes-of-bivalent-metal-ions-with-3-5-dinitrosalicylic-acid.pdf