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Showing posts from May, 2018

Use of Beta vulgaris as natural coloring agent for foods and cosmetics in Libya

ABSTRACT: Color is the main feature of any food item as it enhances the appeal and acceptability of food. Currently, there is increasing awareness among people towards natural dyes and dye yielding plants due to severe health problems. Beet scientifically known as Beta vulgaris belongs to Chenopodiaceae family and locally known in Libyan markets as "Banjer". The present study aimed to study of beet from Libyan markets as coloring agent in food and cosmetic. Beet juice was prepared by hot extraction using methanol and then examined for its activity against bacteria by using the agar well diffusion method and also as antioxidant by using 2,2, Diphenyl-1-picryhydrazyl (DPPH• ) assay. Beet juice also investigated phytochemically which indicated that beet is a rich source of flavonoids. Beet juice examined for the presence of aflatoxines (B1, B2, G1and G2), the beet juice was free from mentioned toxic substances. Therefore, the juice is safe. Finally Beet juice was evaluate...

Biodegradation of sulfonated aromatic amine by Pseudomonas desmolyticum NCIM 2112

ABSTRACT: Environmental pollutions caused by the release of wide range of compounds from various industries such as paper pulp and textiles have a serious effect on ecosystem and human health. Sulphonated azo dyes represent a large class of dyes used in textile industries. The precursors of these dyes are sulphonated aromatic amines. Release of such toxic compounds in the environment cause toxic effects on soil fertility and aquatic ecosystem. Limited attention has been paid towards the fate of sulphonated aromatic amines and substituted sulphonated aromatic amines in the environment previously. The present research work describes biodegradation of azo dye precursor 1- amino 2- napthol 4 - sulphonic acid by Pseudomonas desmolyticum NCIM 2112 which was studied by FTIR and GCMS analysis. The resulting metabolites of biodegradation include propylmethane thiosulfonate and aminobenzene and they were found to be nontoxic in the environment. Further details visit: http://www.jocpr...

Ring transformation of 1,3,4-oxadiazoles into novel [1,2,4]triazolo[3,4- b][1,3,4]thiadiazines and their antimicrobial and antioxidant properties

ABSTRACT: A series of new [1,2,4]triazolo[3,4-b][1,3,4]thiadiazines incorporating α and β-naphthoxy methyl moieties was synthesized starting from S-substituted 5-[(naphthalen-1/2-yloxy)methyl]-1,3,4-oxadiazole-2-thiols. The newly synthesized compounds were characterized by 1H NMR, IR, mass and elemental analysis. The efficacy of the compounds was tried with regard to their antimicrobial and antioxidant properties. Further details visit : http://www.jocpr.com/ For more details PDF Link :  http://www.jocpr.com/articles/ring-transformation-of-134oxadiazoles-into-novel-124triazolo34b134thiadiazines-and-their-antimicrobial-and-antioxidant-p.pdf

Study on physicochemical properties of vegetable oils and their blends use as possible ecological lubricant

ABSTRACT: Vegetable oils due to high biodegrability, low toxicity, renewability and excellent lubricating performance, have immense potential to replace petroleum oils as feedstock for lubricants. In these study vegetable oils like soybean oil, castor oil, groundnut oil, and cottonseed oil was purchased from local super market. The physicochemical properties like viscosity, acid value, saponification value, iodine value of four different vegetable oils and there blends in 10:90 to 90:10 proportion were studied. From this study, it was found that viscosity of pure vegetable oils and there blends regularly decreased with increased in temperature and viscosity of soybean oil blends with castor oil found to be higher than other blenders. Also acid value of same blends found to be lower than other blends. Higher viscosity and lower acid value of castor oil blends in soybean oil suggest that these blends directly use an alternative lubricant for mineral oil based lubricants. Furth...

Study on removal of hexavalent chromium [VI] from aqueous solution using beach sand

ABSTRACT: The use of fine beach sand to remove hazardous Chromium [VI] ions from aqueous solutions was investigated. Removal of chromium ions from stock solution of known concentration of Potassium dichromate was carried out by two sand samples, one pretreated with 70% nitric acid and one washed with distilled water. The experiment was carried out as a function of pH, where the nitric acid pretreated sand had a pH=1, and the water-pretreated sand had a pH=7. The experiment was carried out at room temperature (31°C). The adsorption time for both the solutions was 180 minutes. The main principle of this experiment was the adsorption of chromium [VI] ions to the sand particles. The rate of removal of chromium [VI] ions was observed both qualitatively as well as quantitatively. Higher removal of chromium ions was obtained at pH=1 compared to pH=7 sand samples. For Cr [VI], the Langmuir isotherm gave the best fit for adsorption. The results are discussed in terms of the chromium spec...

Selective and validated spectrophotometric methods for the determination of midazolam using N-Bromosuccinimide

ABSTRACT: Simple and sensitive spectrophotometric methods for the determination of midazolam (MID) are proposed. The methods are based on the bromination of the drug using N-bromosuccinimide (NBS) and the excess oxidant is determined by either malachite green (MG) or safranin O (SO), the absorbances of which are measured at 617 or 522 nm for MID-MG and MID-SO, respectively. Under the optimized experimental conditions, Beer’s law is obeyed in the concentration ranges of 15.00-30.00 and 10.00-50.00 µgmL-1 with molar absorptivity of 8.88 × 103 and 1.18 × 104 L mol-1 cm –1 for methods A and B, respectively. The limits of detection for methods A and B are 1.7368 and 0.5823 g mL-1, respectively. No interference was observed from excipients commonly present in formulations. The proposed methods are applied successfully for the pharmaceutical formulations. Further details visit : http://www.jocpr.com/ For more details PDF Link:  http://www.jocpr.com/articles/selective-and-va...

Hydrochemical characteristics and evolution laws of shallow groundwater in Shuangliao city

ABSTRACT: Shuangliao city is an important part of Weat Liaohe river plain, to ascertain hydrochemical characteristics, origin and evolution of groundwater will be the guiding role to develop and ecological construct to the West Liaohe Plain. In the basis of groundwater flow field, combination of mathematical statistics, correlation analysis, ion scale factor and other methods, hydrochemical characteristics of groundwater will be researched by partition. The result shows that the concentrations of HCO3 - ,Cl- ,Na+ are higher, and these of Ca2+ ,Mg2+ ,SO4 2- ,NO3 - are lower. The concentration of TDS increase gradually in the flow, variation of the concentration of TDS, Cl- ,Na+ , Mg2+,SO4 2- is correlated. Hydrochemical characteristics and evolution laws of shallow groundwater is from HCO3-Ca•Mg to HCO3•Cl-Na•Ca, HCO3•Cl-Na•Mg, and then to Cl•HCO3-Na•Mg. The formation of hydrochemical type was mainly due to the reaction of mineral dissolution, cation exchange and adsorption in th...

Synthesis, spectroscopic, and antimicrobial studies on bivalent Nickel(II) and Copper(II)complexes with 2,6-diacetyl pyridine bisthiosemicarbazone

ABSTRACT: A series of metal complexes of Cu(II) and Ni(II) having the general composition [M(L)X2] with2,6-diacetyl pyridine bisthiosemicarbazonehas been prepared and characterized by elemental chemical analysis,molar conductance,magnetic susceptibilitymeasurements, andspectral (electronic, IR, EPR, mass) studies. The IR spectral data suggest the involvement of sulphur and azomethane nitrogen incoordination to the central metal ion. On the basis of spectral studies, an octahedral geometry has been assigned for Ni(II) complexesbut a tetragonal geometry for Cu(II) complexes. The free ligand and its metal complexes have been tested in vitro against anumber of microorganisms in order to assess their antimicrobial properties. Further details visit : http://www.jocpr.com/ For more details PDF Link:  http://www.jocpr.com/articles/synthesis-spectroscopic-and-antimicrobial-studies-on-bivalent-nickelii-and-copperiicomplexes-with-26diacetyl-pyridine-bi.pdf

Relative analysis of Taekwondo back kick skills’ biomechanics based on 3D photograph parsing

ABSTRACT: As photographing and video parsing techniques improved, it provides a boost for taekwondo technical researching. This paper make analysis of every stage features of back kick skills by using video parsing data, then based on analysis human gravity shifting features and relative features between hip angle and kick velocity in motion process, through analysis of each link of lower limbs’ velocity status in five time phrases, get every links of lower limbs’ velocity feature in 4 stages. With the analysis data of taekwondo back kick motions time consuming in 4 stages, get the order of time consuming proportion from biggest to smallest like : the 4th stage> the 1st stage>the 2nd stage>the 3rd stage; it provides theoretical basis to sports analyzing and data references to taekwondo training. Further details visit : http://www.jocpr.com/ For more details PDF Link:  http://www.jocpr.com/articles/relative-analysis-of-taekwondo-back-kick-skills-biomechanics-...

Kinetic and thermodynamic study of removal of copper from aqueous solution using Senna uniflora (mill.)

ABSTRACT: The application of carbonized senna uniflora (mill.) as a biosorbent for the removal of copper ions from aqueous solutions was investigated. Batch adsorption studies showed that senna uniflora(mill.) was able to adsorb Cu(II) ions from aqueous solutions in the concentration range of 100 – 200 mg L-1. The adsorption kinetics tested with pseudo-first-order and pseudo- second- order models yielded high R2 values. The thermodynamic parameters such as standard Gibb’s free energy (∆G 0 ), standard enthalpy (∆H 0 ) and standard entropy (∆S 0 ) were evaluated by applying the Van’t Hoff equation. The thermodynamics of Cu(II) adsorption onto SUC indicates its spontaneous and endothermic nature. Desorption studies were done using various concentrations of HCl solution. HCl solution of higher concentration shows maximum desorption percentage. The carbonized senna uniflora (mill.) was found to be cost effective and has good efficiency to remove copper ions from aqueous solution. ...

Synthesis of a chiral schiff base derived metal complexes and its antibacterial activity studies

ABSTRACT : Six Potential Tridentate Chiral Schiff base ligands and its metal complex were synthesized and characterized, in that the amino alcohol and 2-amino-3,5-dibromobenzaldhehyde were linked by C=N bond, which can be complexes with metal acetate especially copper and nickel acetate, it has Antibacterial activity against several microbes have been tested and found all six compounds exhibits potential antibacterial activity. Further details for more Articles   : http://www.jocpr.com/ For more details PDF Link :  http://www.jocpr.com/articles/synthesis-of-a-chiral-schiff-base-derived-metal-complexes-and-its-antibacterial-activity-studies.pdf

A Facile β-Cyclodextrin-Catalyzed synthesis of substituted benzofuran from salicyaldehyde and alpha tosyl ketone

ABSTRACT : enzofuranones have attracted considerable attention with regard to their pharmaceutical activity and the various approaches directed towards their synthesis 1 .The simple benzofuran derivatives like 2-nitrobenzofuran2 , 2-acetyl benzofurans are well known as bio-dynamic agents possessing various pharmacological propertiesi.e.spasmolytic activity on the intestine of the guinea pig3 and dilatory effects on the heart of the rabbit4 . Most of the benzofuran compounds frequently occur in natural products and are good chelating agents. The compound amiodarone hydrochloride used as an idealantiarrhythmic drug5 contains a 2, 3-substituted benzofuran moiety. The Schiffs bases exhibit a broad spectrum of pharmacological and biological properties6 such as analgesic, anticancerous, antiinflammatory etc. that may be due to the azomethine linkage. The Schiffs bases bearing methoxy groups have pronouncedantimicrobial activities7 . The Schiffs bases derived from sulfa drugs and salic...

Study on the precision co-extrusion technology for PET recycling

ABSTRACT : The recycling of polyethylene terephthalate (PET) is of significance to the construction of ecological environment, so the recycling technology and relevant equipment has a broad prospect of application. The disadvantage of traditional PET recycling process is analyzed in this paper, the PET precision co-extrusion process is proposed, and the co-extrusion device is designed. Experimental results show that the co-extrusion technology can meet the requirements of large-scale, continuous, precise and high-quality melting and extrusion process of PET recycling. Further details for more Articles   : http://www.jocpr.com/ For more details PDF Link :  http://www.jocpr.com/articles/study-on-the-precision-coextrusion-technology-for-pet-recycling.pdf

Isolation and screening of chitinase producing Serratia marcescens from soil

ABSTRACT : In the present study an attempt was made to isolate organisms that would synthesize chitinase which can be used for the effective biodegradation of a vast majority of crustacean waste. Out of the four isolates screened, the isolate I-3 showed maximum chitinase activity and was selected for further research. The isolate I-3 was identified as Serratia marcescens using the standard identification parameters like gram staining followed by the biochemical assays. Further characterization and purification of chitinase needs to be carried out. Further details for more Articles   : http://www.jocpr.com/ For more details PDF Link :  http://www.jocpr.com/articles/isolation-and-screening-of-chitinase-producing-serratia-marcescens-from-soil.pdf

Biochemical investigation on red algae family of Kappahycus Sp

ABSTRACT : This paper reports the details of experimental investigations carried out on the Kappaphycus sp., a family of red algae. Chemical constituents such as carbohydrates, lipids, proteins, fat, amino acids, fatty acids, phenols, sterols were estimated from Kappaphycus sp. Sample was collected from the sea coast of Rameshwaram, Tamil Nadu, India in the form of wet and living sample. Standard material methods have been followed for estimation of chemical constituents available in Kappaphycus sp. From the experimental studies, it is observed that the carbohydrate available in Kappaphycus alvarezii is 2.67 gm/100gm. The total lipid content is 1.09gm/100gm. The total protein content is very high about 18.78gms/100gm compared to all other substances. Fat content in the species is 1.09gm/100gm. Total phenol content is 4.565gm/100mg. Further, it can be noted that the phenolic content is very much less than proteins but more than carbohydrates, lipids and fats. Further details ...

Physico-chemical study of ground water of some areas of Imphal City, Manipur

ABSTRACT: Eight(8) ground water samples from Imphal City (5 belonging to Imphal East District and 3 belonging to Imphal West District) were analysed for physico-chemical parameters such as colour, odour, temperature,pH, conductivity, TDS (total dissolved solids), total hardness, calcium (Ca), magnesium (Mg) and chloride (Cl). Out of these eight samples, only one sample has parameters within desirable limits of BIS standards and fit for drinking purpose. However, in case of remaining seven samples, some parameters are within desirable limits while some other parameters are within permissible limit of BIS standards, showing that further treatments are required for these seven samples so as to keepthe parameters within desirable limits for drinking purpose mainly though all the samples are fit for other domestic and irrigation purposes. Further details visit : http://www.jocpr.com/ For more details PDF Link:  http://www.jocpr.com/articles/physicochemical-study-of-ground...

Production of activated carbon from local raw materials using physical and chemical preparation methods

ABSTRACT: This study was concentrated on the preparation of activated carbon from local raw material (Rice husk & waste plastic), as they are available in large quantities. A comparison between physical and chemical preparation methods and their efficiency were investigated. Results are shown that the preparation by chemical method is more efficiency than physical method due to bigger surface area of AC, except treatment with NaOH. The optimum preparation conditions together with the effected of these conditions on the yield & efficiency of produced AC have been studied.The maximum surface area of produced AC from rise husks is 201.15 m 2 /gm in physical method and the maximum surface area in chemical method is 329.8714, 280 and 59.0532 when treated with H3PO4, ZnCl2 and NaOH respectively. While the surface area of produced AC from waste plastic is nill that indicate the porosity is not available. Also the characteristic of produced AC were determined such as surface area,...

Synthesis of novel substituted 4H-chromenes and their antioxidant screening

ABSTRACT: Novel substituted 4H-chromenes were synthesized via O-alkylation of 2-amino-7-hydroxy-4-phenyl-4H-chromene-3- carbonitrile (1) followed by hydrazinolysis to give the hydrazide 3. This key intermediate 3 was reacted with aromatic aldehydes, arylmethylenemalononitriles and substituted isothiocyanates to yield compounds 4a&b and 5a&b, respectively. In addition, cyclization of 5a&b in piperidine yielded the target thiazolo derivatives 6a&b. All newly synthesized compounds were evaluated for their in vitro antioxidant activity. Compound 5a was found to be the most potent antioxidant and the least active among the series being compound 1. Further details visit: http://www.jocpr.com/ For more details PDF Link :  http://www.jocpr.com/articles/synthesis-of-novel-substituted-4hchromenes-and-their-antioxidant-screening.pdf

Preliminary phytochemical screening and HPTLC fingerprinting of fruits of three Ficus species

ABSTRACT: India being a rich and varied flora of medicinal plants since the Vedic period. The present study deals with the scientific validation of three Ficus species - Ficus benghalensis (Indian banyan), Ficus racemosa (gular) and Ficus religiosa (bo tree or sacred fig) with special reference to its pharmacognostical and phytochemical investigations. This is commonly known as gular, Indian banyan, sacred fig and is known to have medicinal properties, also even used as home remedies in the rural and the remotest parts of the India. The fruit of Ficus benghalensis used as astringent, haemostatic, anti-septic, anti-inflammatory, antioxidant and anticancer agent and also in the treatment of diarrhoea, dysentery and in the treatment of skin diseases, ulcers, vaginal disorders, leucorrhoea, menorrhagia and deficient lactation, the fruit of Ficus racemosa is medicinally more used for the treatment of diabetes, diarrhoea, dyspepsia, menorrhagia, haemoptysis, intrinsic haemorrhage, exc...

Adsorption of Pb+2 and Zn+2 ions from oil wells onto activated carbon produced from rice husk in batch adsorption process

ABSTRACT: In this work, the adsorption of Pb+2& Zn+2 ions onto activated carbon produced from rice husk(RHAC) was studied, and the efficiency of RHAC has been compared with efficiency of raw rice husk(RH) and commercial activated carbon(CAC) for removal the heavy metal ions from waste oil water which comes out from the oil industry in basrah city. The effects of operating parameters were studied such as (contact time, adsorbent size, adsorbent dose, initial concentration of adsorbate, temperature, pH and rotation speed), and the optimum operating parameters in batch adsorption process were determined. At the optimum conditions the adsorption efficiency is arranged by (RHAC > CAC >RH) which removed 96.26, 95.71, 81.06% of Pb+2 ions, and 92.51, 83.32, 53.28% of Zn+2 ions. Further details visit : http://www.jocpr.com/ For more details PDF Link :  http://www.jocpr.com/articles/adsorption-of-pb2-and-zn2-ions-from-oil-wells-onto-activated-carbon-produced-from-ric...

New bio-sorbents in the removal of brilliant gree dye from polluted waters

ABSTRACT: Powders of leaves, stems and their ashes of Thespesia populnea, Pongamia pinnata and Aeschynomene aspera are found to have strong affinity towards cationic Brilliant Green Dye at high pH values. The sorption characteristics of these bio-products in controlling the Dye pollution in waste waters, are studied by varying physicochemical parameters such as pH, sorption concentration and equilibration time using simulated waste waters. The conditions for maximum extraction of the Dye have been optimized. Fivefold excess of common anions ions present in natural waters, have marginal interference on the % of extraction while Cation like Ca2+, Mg2 and Cu2+ have shown some interference but Fe2+ and Zn2+ have synergistically maintained the maximum extraction of the Dye at optimum conditions of extraction. The methodologies developed in this work have been applied to diverse waste water samples collected in different industries and are found to be remarkably successful. Furthe...

New medicinal family recorded for Sudan flora (Martyniaceae, species: Proboscidea parviflora subsp. parviflora)

ABSTRACT: Proboscidea parviflora (Wooton.) Wooton.& Standl.subsp. parviflora is a flowering plant that has been recently collected from Sudan ( Feddasi El Halimab area at Eljezira state). This collection represents the first records for this species, the genus Proboscidea and the family Martyniaceae in Sudan. From the literature this family is known to have medicinal uses. Further details for more Article s: http://www.jocpr.com/ For more details PDF Link :  http://www.jocpr.com/articles/new-medicinal-family-recorded-for-sudan-flora-martyniaceae-species-proboscidea-parviflora-subsp-parviflora.pdf

Molecular and atomic spectrophotometry and high performance liquid chromatographic determination of metronidazole in dosage forms via complex formation with Au(III) and Hg(II) ions in Solutions

ABSTRACT: Uv-visible spectrophotometry, flame atomic absorption spectrophotometry and HPLC techniques have been developed for the assay of metronidazole in bulk drug and in dosage forms via complex formation with Au(III) and Hg(II) ions in solutions after fixing maximum reaction conditions . In the first two techniques, chloroform was used as a solvent for the two complexes with extraction percentages (96.652,93.975%) respectively. Stability constants for the two extracted complexes were (1.697x104 , 5.118x105 )respectively. Beer's law was obeyed for (5-55), (2- 22µg/ml) for uv-visible and atomic spectrophotometric methods respectively. The HPLC determination for metronidazole and its complexes was performed simultaneously without extraction or separation step with peak absorption at λ(272nm), (280nm) for Au and Hg complexes respectively. A rectilinear relationship between two mean peaks area for metronidazole and its complexes with concentrations was observed in the range (...

Optimization of citric acid and malic acid to enhance flavour and shelf life of mango juice

ABSTRACT: Mango (Mangifera indica) is one of the most delicious seasonal fruit, rich in nutrient with unique flavour, fragrance, and taste making it as a common ingredient in fruit based product. Nowadays many industries have been developing various type of mango flavoured product such as soft drink, ice-cream, jams, jellies, fruit cheese etc. In industry to enhance flavour and shelf life of mango fruit various flavouring agent and preservatives are added. Some common organic acid which naturally occur in fruit are also used to enhance flavour and shelf life of product. Generally citric acid is used but in this investigation mixtures of citric acid and malic acid have been used to enhance sensory attribute and shelf life of mango juice. Sensory analysis was done by 50 volunteer in which sensory attribute such as flavour, sweetness, sourness, overall taste, after taste sweetness and after taste sourness of the juice were evaluated and obtained data was analysed by SPSS software. ...

Antibacterial bioassay and computational studies of various novel naphthyridine series

ABSTRACT: The biological evaluation, QSAR and docking studies ofNaphthyridine derivatives are carried out to optimize their inhibitory activity against DNA topoisomerase. The biological activities of these derivatives are correlated to different molecular properties. The AM1and PM3 semi empirical methods are used to estimate vertical ionization potentials (IPv’s), electron affinity (EA) , electro negativity (χ), hardness (η), softness (S), electrophilic index (ω), partition coefficient (LogP),hydration energy(HE), ionization potential(IP) and charges. The different modeled equations are proposed by regression analysis. The leave-one-out cross-validation method is used to estimate the predictive power of final QSAR equations. The hardness (η), was found to be indicative molecular property by regression analysis. Docking studies of naphthyridines with DNA topoisomerase were made to support the finding of QSAR studies. Analysis of results of both QSAR and Docking studies suggested ...

Rapid Separation of Five Anti-Hypertensive Agents - Atenolol, Metoprolol, Hydrochlorothiazide, Amlodipine and Nebivolol: Application to Estimation of Metoprolol Succinate in Tablet Dosage Form

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ABSTRACT: One of the key goals of High Performance Liquid Chromatography technique is to achieve a consistent and reproducible separation. A simple, precise, selective and sensitive HPLC method with UV detection was developed for separation of five anti-hypertensive agents, atenolol hydrochloride, metoprolol succinate, hydrochlorothiazide, amlodipine besylate and nebivolol hydrochloride and validated for determination of metoprolol succinate. RPHPLC method was developed by using Welchrom C18Column (4.6 mm i.d. X 250mm, 5µm), Shimadzu LC-20AT ProminenceLiquid Chromatograph. The mobile phase composed of10 mM Phosphate buffer (pH3.0,adjusted with triethylamine): acetonitrile(50:50, v/v).The flow rate was set to 1.0 ml/min with the responses measured at 235nm using Shimadzu SPD-20A Prominence UV-Visible detector. The retention times of atenolol hydrochloride, Metoprolol succinate, hydrochlorothiazide, amlodipine besylate and nebivolol hydrochloride were found to be 2.303 min, 2.827 ...

Synthesis and characterization of some new 3, 5-disubstituted pyrimidine and thiopyrimidine derivatives

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ABSTRACT: 1-(5-chloro-2-hydroxyphenyl)-ethanone (1a) was prepared from 2-chlorophenol through multi-step reaction. Compound (1a) reacts with different aryl aldehyde in the presence of NaOH (40%) to gives 1-(5-chloro-2- hydroxyphenyl)-3-(4-substitutedphenyl)-prop-2-en-1-one (2a-e). 4-(5-chloro-2-hydroxy phenyl)-6-(4-substituted phenyl)-pyrimidin-2-(1H)-one (3a-e) and 4-(5-chloro-2-hydroxyphenyl)-6-(4-substitutedphenyl)-pyrimidin-2-(1H)- thione (4a-e) was achieved through cyclisation of 1-(5-chloro-2-hydroxyphenyl)-3-(4-substitutedphenyl)-prop-2-en1-one (2a-e) with urea and thiourea in ethanol containing catalytic amount of KOH respectively. All the synthesized compounds were characterized on the basis of spectral data. Further details for more Articles : http://www.jocpr.com/ For more details PDF Link :  http://www.jocpr.com/articles/synthesis-and-characterization-of-some-new-3-5disubstituted-pyrimidine-and-thiopyrimidine-derivatives.pdf

Concentration change and clinical significance of plasma S100 protein in cardiopulmonary bypass perioperative period

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ABSTRACT: To seek for evaluation indicators of cerebral injury in cardiopulmonary bypass (CPB) perioperative period and discuss the change and clinical significance of S100 protein in CPB perioperative period. 40 patients of congenital heart disease or heart valve disease were subject to open-heart surgery under CPB. The occurrence of neurological complications in perioperative period was observed. The concentration of plasma S100 protein was measured at different time points in CPB perioperative period. 3 cases of neurological complications occurred after surgery, including 2 cases of mental symptom and 1 case of cerebral infarction. The start of CPB caused great increase of S100 protein plasma concentration which recovered to the preoperative level 24 to 48 hours after surgery. Patients with neurological complications had a significantly higher S100 protein concentration than those without neurological complications and their S100 protein concentration still maintained a high ...

An expeditious and efficient microwave assisted synthesis of 1,5-benzodiazepine derivatives

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ABSTRACT: The present work reports eco friendly synthesis of a new series of 2,4-disubstituted-1,5-benzodiazepine derivatives which is achieved by the condensation of o-phenylenediamine and various substituted chalcones under microwave irradiation. The structures of the synthesized compounds were confirmed through IR and 1H NMR spectroscopy. This method is based on the principles of ‘Green Chemistry’, rendering the method to be facile, efficient and environmentally benign. It afforded all the synthesized compounds in good to excellent yields and the reaction time was considerably short. The clean reaction conditions, easy work-up, time saving and higher yields are notable advantages of the present method. Further details for more Articles : http://www.jocpr.com/ For more details PDF Link :  http://www.jocpr.com/articles/an-expeditious-and-efficient-microwave-assisted-synthesis-of-15benzodiazepine-derivatives.pdf

In vitro antibacterial activity of the fern, Actiniopteris radiata (Sw.) Link. inhabiting the Shervaroyan Hills, the Eastern Ghats.

ABSTRACT: The present study was undertaken to investigate the antibacterial activity of the fern, Actenopteris radiata by well diffusion method. The whole plant was extracted successively with certain alcoholic and aqueous solvents (petroleum ether, chloroform, acetone, methanol and water) by using soxhlet apparatus. Different concentrations of crude extracts such as 100, 200 and 300 µg/mL were prepared to found antibacterial activity. Chloramphenicol was used as a positive control. The results of the study revealed that water and methanolic extracts of the plant had strong antibacterial activity in all the concentrations than the other solvents used. Therefore, the plant extract may be used to control the diseases caused by pathogenic bacteria.   Further details for more Articles : http://www.jocpr.com/ For more details PDF Link :  http://www.jocpr.com/articles/in-vitro-antibacterial-activity-of-the-fern-actiniopteris-radiata-sw-link-inhabiting-the-shervaroyan-...

Ethylene-regulation of fruit softening and cell wall enzymes activities during peach storage

ABSTRACT : ‘Yanhong’ peach fruits were treated with 1 mg/g ethrel and 2 µl/l 1-methylcyclopropene and stored at room temperature for 12 days. Ethylene production, firmness, and the activities of polygalacturonase, endo-1,4-β-glucanase, β-galactosidase, α-L-arabinofuranosidase and endo-β-mannanase in ‘Yanhong’ peach were monitored during storage. Control fruit displayed a typical climacteric pattern of ethylene production and the early softening of peach fruits started before the climactic stage. Ethrel promoted the decrease in firmness and onset of ethylene production. In contrast, 1-methylcyclopropene treatment delayed the decline in fruit firmness and onset of ethylene production. The activities of polygalacturonase, endo-1,4-β-glucanase, β-galactosidase, α-L-arabinofuranosidase and endo-β-mannanase in both epicarp and mesocarp tissue were enhanced by exogenous ethrel and inhibited by 1-methylcyclopropene during storage. Additionally, most activities of β-galactosidase, α-L-ar...

Characterization and evaluation performance of activated carbon prepared from coconut shell argan

ABSTRACT : The objective of this study is the valorization of a sub-product of the fruit of the argan tree; it is the shell of argan nuts which represents about 50% of fresh fruit. It is a natural lino-cellulosic residue that we could turn into charcoal under the effect of chemical activation with phosphoric acid which allows the development of a large pore in the activated material. We studied the effect of the activation temperature, activation time and the amount of acid added to the char yield and the adsorption capacity of the material developed in response to the experimental determination of the kinetics of adsorption of an organic molecule: the methylene blue. The results showed that the temperature of 400 °C, the processing time of one hour and the mass ratio (precursor/phosphoric acid) equal to one, are optimal conditions for development of the adsorbent material. The product obtained under these conditions has good textural and structural properties; a specific surfac...

Adosrption of Rhodomine B on different plant leaf powder

ABSTRACT : Dyes from industrial and laboratory waste are major water pollutants. Most of the dyes are stable to degradation. In this, the removal of Rhodamine-B from its aqueous solutions by adsorption on different plant leaf powder such as Annona squamosa, Manilkara zapota and Prosopis julifora were studied. The effects of various experimental parameters on adsorption such as pH, dye concentration and sorbent dosage were examined and the optimal experimental conditions were evaluated. The maximum removal of color was achieved by Annona squamosa with dosage of 1gm/100ml of effluent at neutral pH. In acidic pH (5.6) Manilkara zapota reduced more color (68.33%). Further details for more articles: http://www.jocpr.com/ For more details PDF Link :  http://www.jocpr.com/articles/adosrption-of-rhodomine-b-on-different-plant-leaf-powder.pdf

Study on the system dynamic model of sustainable development of the island: A case study on Pingtan

ABSTRACT : Due to the special geographical position and the fragile ecological environment, it is necessary to attach great importance to the analysis of the sustainable development in the sea island city. Based on the system dynamic theory and method, a system dynamic model of sustainable development of Pingtan Island is constructed. The model consists of four subsystems: economic, social, resources, environmental. Several plans are formulated for simulation prediction and research. Simulation result shows that the sustainable development ability of Pingtan can be improved gradually in the aspects of the conditions of transportation, health care and education; implementing the project of water diversion from outside the island; controlling the population size, improving the environmental quality of the island, and increasing the investment index of environmental protection. According to the results, some control measures are proposed, which can be used as the scientific basis f...

A mechanistic study based on kinetics of the oxidation of diethyl ketone by Ir (III) chloride in aqueous perchloric acid medium when cerium (IV) perchlorate is used as a catalyst

ABSTRACT : This mechanistic study on the oxidation of diethyl ketone by Ir (III) chloride in aqueous perchloric acid medium when cerium (IV) perchlorate is used as a catalyst has been done at temperature range of 293 to 308 K under conditions such that, [Ir]T << [Ce (IV)]T << [CH3-CH2-CO-CH2-CH3] so that the reaction constants of different steps involved have been evaluated with great ease and accuracy the rate of reaction tends towards zero-order at higher concentration and first order at lower concentration with respect to ceric perchlorate and diethyl ketone. Order of reaction is unity with respect to [Ir (III)] in the concentration range studied. On increasing the concentrations of [H+ ] the rate decreases slightly. The effect of ionic strength and the dielectric constant on reaction rate has also been studied. The active species of oxidant is indicated to be Ce4+ and Ce (OH)3+. An intermediate involving the oxidant, catalyst and substrate has been proposed as be...

Effect of solvent extraction system on the antioxidant activity of some selected wild edible fruits of Meghalaya state in India

ABSTRACT : The present communication deals with the antioxidant activity of the benzene, chloroform, acetone and methanol extracts of five wild edible fruits e.g. Zanthoxylum armatum, Gomphogyne cissiformis, Gymnopetalum cochinensis, Artocarpus gomeziana, and Baccaurea sapida collected from Meghalaya state in India. The total phenolic content varied from 0.72 ±0.34 to 4.30±0.53 mg/g, 0.19 ±0. 11 to 4.89±0.86 mg/g, 1.58 ±0.21 to 34.24±0.25 mg/g and 21.14 ± 0.23 to 96.19 ± 1.18 mg/g dry material in t he benzene, chloroform, acetone and methanol extracts of the fruits respectively. Flavonoids and flavonols content were found highest in the acetone extract of Gymnopetalum cochinensis whereas least amount of flavonoids present in the acetone extract of Baccaurea sapida. 1,1-diphenyl2-picryl hydrazyl (DPPH) radical scavenging effect of the extracts was determined spectrophotometrically. The highest radical scavenging was observed in the methanol extract of Artocarpus gomeziana with IC...

Sapflow characteristics of mangrove Avicinia marina and its affecting factors in Zhangjiang estuary

ABSTRACT : Xylem sapflow of Avicinia marina (Forsk.) Vierh (A. marina) and environment factors were investigated over a year period (June 2011 to May 2012) by continuous sapflow density (SFD) measurements in Zhangjiang estuary in Yunxiao County of Fujian province, China. Diurnal SFD patterns for A. marina belonged to single curves following the variation of photosynthetically active radiation (PAR) and vapor pressure deficit (VPD,) but time lag between sapflow and PAR as well as VPD in both a wet month (summer) and a dry month (winter) are discussed .PAR exhibited diurnal peak values earlier than sap flow by 30 min (winter) to 60 (summer). However, VPD lagged behind sapflow by 30 in winter and earlier than sap flow by 30 min in summer. The sapflow rate of A. marina was much higher than those of terrestrial tree species.  However, the daily water use was still conservative. Daytime half-hourly mean stand sapflow was positively linearly correlated with photosynthetically a...

Ultrasonic studies on molecular interaction of benzaldehyde, cinnamaldehyde, 4-methoxy benzaldehyde and diethylamine in n-hexane solutions at 303K

ABSTRACT : Ultrasonic velocities(U), Densities(ρ), Viscosities(η), are measured for three different aromatic carbonyl compounds (Benzaldehyde, Cinnamaldehyde, 4-methoxy benzaldehyde) and Diethylamine in n-hexane solutions containing equimolar concentrations (1x10-4M to 1x10-3M) at 303K. The interaction between solvent molecules and Carbonyl compounds - Diethyl amine complexes are observed. Acoustical parameters such as adiabatic compressibility (κ), free length (Lf), internal pressure(πi), cohesive energy(CE), formation constant(K) values are also calculated. These values indicate complex formation and ion-solvent interaction between aromatic carbonyl compounds and diethylamine in n-hexane medium. For more Articles: http://www.jocpr.com/ Further details PDF Link:   http://www.jocpr.com/articles/ultrasonic-studies-on-molecular-interaction-of-benzaldehyde-cinnamaldehyde-4methoxy-benzaldehyde-and-diethylamine-in-nhe.pdf

Molecular interaction studies on pharmaceutical drug of 2-[1-(aminomethyl) cyclohexyl] acetic acid in water of various concentrations at 303K

ABSTRACT : The measurement of ultrasonic velocity in pure liquids and mixtures is an important tool to study the physico- chemical properties and also explains the nature of molecular interactions. The study of thermodynamic parameters to explain molecular interaction of drugs in aqueous or non- aqueous medium provides useful information in medicinal and pharmaceutical chemistry. In present work molecular interaction of aqueous solution of 2-[1-(aminomethyl) cyclohexyl] acetic acid at different concentrations at 303K was studied by measuring ultrasonic velocity, density and viscosity of the solution. The ultrasonic parameters such as adiabatic compressibility, free volume, free length, acoustic impedance, absorption coefficient, viscous relaxation time, available volume and Lenard Jones Potential were calculated. These parameters explained formation of hydrogen bond and molecular interaction existing in the solution.  Further details PDF Link:  http://www.jocpr.com/ar...

Preparation of chlorothalonil microcapsules by interfacial polymerization

ABSTRACT : Chlorothalonil, a kind of antiseptic used widely, has special control effect on plant disease caused by fungus of fruits. Its existing dose forms have many disadvantages including active ingredients exposing in wind, rain and sunshine, easy decomposition and volatilization. In order to solve above-mentioned problems, the best way is to microencapsulate chlorothalonil. In the study, chlorothalonil microcapsules were prepared by interfacial polymerization with toluene-2,4-diisocyanate and hexamethylenetetramine as wall materials. By large number of pre-experiments, the optimal shear speed, shear time, stirring speed, stirring time and suitable solvents used in preparation process of chlorothalonil microcapsules were determined. By orthogonal experiments, the optimal ratio of wall materials, solvent and dispersant were determined with encapsulation efficiency measured by ultraviolet spectrophotometry as indicator. The particle size distribution of chlorothalonil microcap...

In vitro anti-microbial and DNA cleavage studies of benzimidazole derivatives

ABSTRACT : The increase in bacterial resistance has attracted considerable interest in the discovery and development of new classes of antibacterial agents. The new agents should preferably consist of chemical characteristics that clearly differ from those of existing agents. Benzimidazoles are remarkably effective compounds both with respect to their bacteria inhibitory activity and their favorable selectivity ratio. Extensive biochemical and pharmacological studies have confirmed that these molecules are effective against various strains of microorganisms. Some benzimidazole compounds inhibit the biosynthesis of ergosterol, required in the cell membrane of fungi. They have antibacterial, antifungal, and antiviral activity. This ring system is present in numerous antiparasitic and antitumoral drugs. The benzimidazole structure is part of the nucleotide portion of vitamine B12 and the nucleus of some drugs, such as proton pump inhibitors and anthelmintic agents. Proton pump inhi...

Determination of pyrethroid pesticide residues in rice by gas chromatography tandem mass spectrometry

ABSTRACT : A simple and sensitive method for the determination of pyrethroid pesticide residues namely transfluthrin, allethrin, bifenthrin, lambda cyhalothrin, permethrin, cyfluthrin, cypermethrin, ethofenprox, fenvalerate, tauflivalinate & deltamethrin in rice grains by gas chromatography –tandem mass spectrometry (GC-MS/MS) was developed. The pyrethroid residues were extracted from homogenized rice samples initially with water followed by acetonitrile and cleaned up by using dispersive solid phase extraction which is based on QuEChERS (quick, easy, cheap, rugged and safe) method, finally the pyrethroid pesticide residues were separated by DB-5MS gas chromatography capillary column and quantified through tandem mass spectrometry (GC-MS/MS) with electron ionization source in Multiple reaction monitor mode (MRM) for quantification and confirmation. Recoveries were checked at two fortification levels 0.01 and 0.05mg/kg (n=6). The results showed that the mean recoveries for th...

Synthesis of some new cyclohexene carboxylic acid derivatives as potent antitumor agents

ABSTRACT : Cyclohexenone derivative (2) prepared by reaction of butanoic acid (1) with ethyl acetoacetate reacts with aromatic aldehydes, hydrazine hydrate, thiosemicarbazide to give arylidene, indazole and thiotriazole derivatives. The behavior of the obtained thiotriazole towards hydrazine hydrate, aromatic amines, sodium nitrite, acetylacetone, anthranilic acid, thiourea, benzalacetophenone has been studied. The structure of all synthesized compounds were confirmed by micro analytical and spectral data. The antitumor activity of some of the synthesized compounds were tested. For more details Home Page URL : http://www.jocpr.com/ For more details PDF Link:  http://www.jocpr.com/articles/synthesis-of-some-new-cyclohexene-carboxylic-acid-derivatives-as-potent-antitumor-agents.pdf

Development, validation and application of UV spectrophotometric method for the determination of roxithromycin in bulk and pharmaceutical dosage form

ABSTRACT : Roxithromycin is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. The present research work discussed the development of a simple, sensitive, rapid, accurate, precise and economical UV Spectrophotometric method for the evaluation of Roxithromycin in bulk and pharmaceutical dosage form which is based on the measurement of absorption maxima at 420 nm. A Shimadzu 1800 U.V visible spectrophotometer with 1cm matched quartz cells, and de-ionized water as solvent were used. Developed methods obeyed the Beer’s law in the concentration range of 20-70μg/ml having line equation y = 0.020x + 0.168 with correlation coefficient of 0.999.Method was validated statistically. Percentage recovery of the drug for the proposed method ranged from (99.2280-99.5320 ±0.1670) indicating no interference of the capsule excipients. The developed method was validated with respect to precision, accuracy (recovery), linearity, limit of...

Calculation of absorption spectrum of the Ag Bu 1 1 1 →1 electronic transition of trans-1,3,5-hexatriene based on frequency-domain approach

ABSTRACT : The general expressions we previously derived for calculating of the vibronic structure in electronic absorption spectrum of a large polyatomic molecule based on frequency-domain approach (J. Molec. Spectrosc.2013, 286-287, 30-45) are applied to simulate the vibronic structure in the dipole-allowed Ag Bu 1 1 1 →1 electronic transition of trans-1,3,5-hexatriene molecule. The calculated results indicated that spectral profiles are primarily described by the Franck-Condon progression of four totally symmetric modes, ν 5 , ν 10 , ν 11 and ν 13 , among which the ν 5 (CC double bond stretch) and ν 10 (CC single bond stretch) are the longest progression-forming modes, while the modes ν 11 and ν 13 have much less activities. The spectra also show combination bands (as 11 115 , 11 105 , etc.) produced by the ag modes. For more details Home Page URL : http://www.jocpr.com/    For more details PDF Link:  http://www.jocpr.com/articles/calculation-of-absorption...

Characterization of aviation turbine fuel with spindle oil

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ABSTRACT: Study has been conducted on Aviation Turbine Fuel with spindle oil and result was analysed based on different physical parameters like Density, Kinematic Viscosity and Aniline point. These parameters show a characteristic change in the behaviour of aviation turbine fuel, when mixed with spindle oil.    For Home Page URL :  http://www.jocpr.com/ For more details PDF Link:    http://www.jocpr.com/articles/characterization-of-aviation-turbine-fuel-with-spindle-oil.pdf   

Synthesis, physicochemical and biological evaluation of Co (II) complexes derived from 5-chloro-2-hydroxy acetophenone N(4) methyl thiosemicarbazone

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ABSTRACT : Heterocyclic base adducts of cobalt (II) complexes have been synthesized by the reaction of cobalt (II) chloride with 5-chloro-2-hydroxy acetophenone N(4) methyl thiosemicarbazone in presence of heterocyclic base like pyridine (py), 2,2’-bipyridine (bipy), 1,10-phenanthroline (Phen), α/β-picoline. The synthesized thiosemcarbazone has been characterized by 13C, 1H NMR as well as IR, electronic spectra. The magnetic and spectroscopic study show octahedral geometry for six coordinate, square planner geometry for the four coordinate and a distorted square pyramidal for five coordinate complexes. The thiosemicarbazone and its cobalt (II) complexes exhibit growth inhibitory activity against Pseudomonas Putida, Escherichia Coli, Aspergillus Niger and Candida Albicans. Thiosemicarbazone and its cobalt (II) complexes have also been found antioxidant.  For Home Page URL :  http://www.jocpr.com/ For more details PDF Link:    http://www.jocpr.com/ar...

Synthesis, characterization and antimicrobial evaluation of novel compounds 1(-benzo[d]oxazol/thiazol-2-yl)-methyl-6-phenoxy-4,8-dihy

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ABSTRACT: New novel derivatives of 1-(5/6-mono substituted or 5,6-disubstituted benzo [d] oxazol-2-yl) methyl)-6-(4- substituted phenoxy)-4,8-dihydro-1H-[1,3,2] dioxaphosphepino [5,6-d] imidazole-6-oxide (8a-f as per Scheme-1) were prepared by condensation of 4-substituted phenyl phosphorodichloridates (7a-f) with 1-(5/6-mono substituted or 5,6-disubstituted benzo [d] oxazol-2-yl)methyl) -1H-imidazole-4,5-diyl) dimethanol (6a-f). The synthons (6a-f) obtained by deprotection of isopropylidene of 1-(5/6-mono substituted or 5,6-disubstituted benzo [d] oxazol-2-yl) methyl)-6,6-dimethyl-4,8-dihydro-1H-[1,3]- dioxepino [5,6-d] imidazole (5a-f). The synthons (5a-f) were obtained by the reaction of 2-(6, 6-dimethyl-4,8-dihydro-1H-[1,3] dioxepino[5,6-d] imidazole-1-yl) acetic acid (3) with 4/5- mono substituted or 4,5-di substituted 2-amino phenols (4a-f). Similar procedure was adapted to prepare 1-( benzo [d] thiazol-2-yl ) methyl ) -6-(4-substituted phenoxy)-4,8-dihydro-1H-[1,3,2] diox...